血必净对颅脑外伤后神经源性肺水肿患者肺功能及血浆TNF-α、IL-6水平的影响  

Effects of Xuebijing administration on pulmonary function and levels of serum tumor necrosis factor-α and interleukin-6 in patients with neurogenic pulmonary edema after severehead trauma 1

作　　者：杨新翔[1] 蒋宝虎[1] 吴衡[1] 

机构地区：[1]江苏大学附属宜兴市人民医院ICU,214200

出　　处：《临床神经外科杂志》2011年第2期68-69,共2页Journal of Clinical Neurosurgery

摘　　要：目的探讨血必净注射液对重型颅脑损伤引起的神经源性肺水肿患者(NPE)肺功能及血浆肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平的影响。方法将38例NPE患者随机分为治疗组和对照组,分别检测两组治疗前、治疗后1 d、4 d、7 d的血浆TNF o、IL-6水平。结果 4d、7d血浆TNF-α、IL-6水平与对照组比较有显著降低(P<0.01)。结论血必净注射液对重型颅脑损伤后神经源性肺水肿(NEP)患者的肺功能有一定的保护作用。Objective To investigate the effects of Xuebijing administration on pulmonary function and levels of serum tumor necrosis factor-α （TNF-α） and interleukin-6 （ IL-6 ） in patients with neurogenic pulmonary edema （NEP） after severe head trauma. Methods 38 patients were randomly divided into treated and control group. The level of TNF-α and IL-6 of two groups were respectively detected before and on 1 d ,4 d ,7 d after Xuebijing administration. Result The level of TNF-α and IL-6 in the treated group were significantly lower than in the control group on the fourth and seventh day after Xuebijing adminstration. Conclusion Xuebijing has certain protective effects on pulmonary function in patients with NEP after severe head trauma.

关 键 词：神经源性肺水肿 肿瘤坏死因子-Α 白细胞介素-6 

分 类 号：R264[医药卫生—中医外科学]