头孢曲松钠致胆囊结石的不良反应分析  

Analysis of Ceftriaxone Sodium-induced Cholecystolithiasis

作　　者：程志英[1] 史保权 王莉[1] 

机构地区：[1]武警总医院,北京100039 [2]武警河北总队医院,石家庄050081

出　　处：《中国医院用药评价与分析》2011年第4期373-375,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨头孢曲松钠导致胆囊结石不良反应的特点及相关因素,为临床合理用药提供参考。方法:对国内发表的使用头孢曲松钠出现的胆囊结石不良反应报道进行统计和分析。结果:检索到头孢曲松钠引起的胆囊结石不良反应166例。不良反应的发生男性多于女性,儿童患者应用头孢曲松钠诱发的胆囊结石数量较多,应引起重视。头孢曲松钠致胆囊结石在B超和CT均有表现。停药后未经特殊治疗结石多数自行消失。结论:临床应重视头孢曲松钠所致的胆囊结石不良反应,用药时注意患者的临床表现,减少不良反应的危害。OBJECTIVE： To investigate the characteristics and associated factors of the adverse reactions of cholecystolithiasis caused by ceftriaxone sodium so as to provide references for clinical rational use of ceftriaxone sodium.METHODS： The adverse reactions of cholecystolithiasis caused by ceftriaxone sodium reported in domestic journal were analyzed statistically.RESULTS： 166 ceftriaxone sodium-induced cholecystolithiasis cases were collected,which were more often seen in males than in females.The incidence of sodium-induced cholecystolithiasis was higher in pediatric patients,which should be given highly attention.Ceftriaxone sodium-induced cholecystolithiasis can be detected in B ultrasonography and CT.The symptom in most cases resolved on their own after discontinuation of ceftriaxone sodium.CONCLUSION： Great attention should be paid to ceftriaxone sodium-induced cholecystolithiasis and the clinical manifestations of the patients when using ceftriaxone sodium so as to avoid damage of the adverse drug reactions.

关 键 词：头孢曲松钠 不良反应 胆囊结石 分析 

分 类 号：R978.11[医药卫生—药品]