多巴酚丁胺负荷组织速度成像与心肌SPECT诊断老年冠心病的对比观察  

Comparison of dobutamine stress tissue velocity imaging and myocardial SPECT for detecting coronary artery disease in elders

作　　者：张妮[1] 何青[1] 汪芳[1] 李靖[1] 王海燕[1] 尹东梅[1] 

机构地区：[1]卫生部北京医院心内科,北京100730

出　　处：《中国医学影像技术》2011年第4期727-730,共4页Chinese Journal of Medical Imaging Technology

基　　金：中央保健科研课题(2006.005)

摘　　要：目的以CAG为金标准,与ATP负荷99mTc-MIBI心肌SPECT对比,探讨多巴酚丁胺负荷定量组织速度成像(DSE+QTVI)诊断老年冠心病的临床价值。方法 98例入选者接受DSE+QTVI,其中40例接受ATP负荷SPECT检查,并均在2周内接受CAG。在DSE+QTVI检查过程中测定不同多巴酚丁胺负荷剂量时各室壁中段收缩期心肌运动峰值速度(Vpeak)。结果 Vpeak在多巴酚丁胺20μg/(kg.min)负荷量时其诊断老年冠心病的敏感度和特异度最高,分别为80.43%、81.58%;在多巴酚丁胺40μg/(kg.min)负荷剂量时,敏感度和特异度最低,分别为52.94%、69.57%。与ATP负荷SPECT相比,Vpeak诊断老年冠心病的敏感度、特异度略低。结论 DSE+QTVI诊断老年冠心病是安全、有效、无创的方法。Objective Taking CAG as a gold standard,to observe the clinical value of dobutamine stress quantitative tissue velocity imaging（DSE＋QTVI） in diagnosis of aging patients with suspected coronary artery disease comparing with ATP stress 99mTc-MIBI myocardial SPECT.Methods Ninty-eight subjects underwent DSE＋QTVI,ATP stress myocardial SPECT,and then CAG within 2 weeks.Mid-wall myocardial peak tissue velocity（Vpeak） in systolic period was measured in different dobutamine stress stations.Results At the dobutamine dose of 20 μg/（kg·min）,Vpeak had maximum sensitivity and specificity（80.43%,81.58%） in diagnosis of coronary artery disease.However,at the dose of 40 μg/（kg·min）,the sensitivity and specificity of Vpeak was the minimum（52.94%,69.57%）.Compared with ATP stress myocardial SPECT,Vpeak had lower sensitivity and specificity.Conclusion DSE＋QTVI is a safe,effective and non-invasive technique for detecting coronary artery disease in elders.

关 键 词：多巴酚丁胺 组织速度成像 心肌 体层摄影术 发射型计算机 单光子 冠状动脉疾病 老年人 

分 类 号：R816.2[医药卫生—放射医学] R814.42[医药卫生—临床医学]