二甲双胍的心血管保护作用  

Cardiovascular protective effects of metformin

作　　者：方丽娟[1] 刘乃丰[1] 

机构地区：[1]东南大学附属中大医院心血管病研究所

出　　处：《中国临床药理学与治疗学》2011年第2期232-236,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：二甲双胍(Metformin)属双胍类药物,作为口服降糖药应用于2型糖尿病(T2DM)已有50年的历程,其降糖作用已得到公认。近年越来越多的研究发现,二甲双胍具有降糖以外的心血管保护作用,能抑制动脉粥样硬化(Atherosclero-sis,AS)、心衰、心肌梗死等心血管病的发生和发展。但二甲双胍确切的心血管保护机制仍不明确,本文综述了二甲双胍对心血管疾病的作用,并探讨其可能的作用机制。Metformin belongs to biguanide drugs,used as oral hypoglycemic agents in type 2 diabetes（T2DM） for 50 years,and its anti-hyperglycemic effect has been recognized.Furthermore,in recent years more and more studies found that metformin has additional cardiovascular protective effects,including the inhibition of atherosclerosis（AS）,heart failure and myocardial infarction.However,the specific effect of metformin on cardiovascular protection is still unclear.This article reviews the effect of metformin in cardiovascular disease and discusses its possible mechanisms.

关 键 词：二甲双胍 动脉粥样硬化 心衰 心肌梗死 

分 类 号：R977.15[医药卫生—药品]