非酒精性脂肪肝炎肥胖儿童胰岛素和瘦素抵抗研究  

The study of insulin and leptin resistence in obese children with nonalcoholic steatohepatitis

作　　者：杨卫霞[1] 黄锋[1] 吴尤佳[1] 徐杰[1] 孙宝兰[1] 龚红蕾[1] 

机构地区：[1]南通大学附属医院儿内科,南通226001

出　　处：《南通大学学报（医学版）》2011年第2期119-120,124,共3页Journal of Nantong University(Medical sciences)

基　　金：南通大学附属医院科研基金资助项目(Tdfy0980)

摘　　要：目的:探讨肥胖儿童非酒精性脂肪肝炎(NASH)与胰岛素、瘦素抵抗的关系。方法:对符合NASH诊断的23例患儿,符合单纯性肥胖诊断的17例儿童及20例正常儿童分别检测血谷丙转氨酶、游离脂肪酸、甘油三酯、胰岛素、瘦素,比较它们的水平并分析谷丙转氨酶与各指标的关系。结果:NASH组患儿血游离脂肪酸、甘油三酯、胰岛素、瘦素水平高于单纯肥胖组和对照组(P<0.05)。相关分析显示谷丙转氨酶与游离脂肪酸、甘油三酯、胰岛素、瘦素和HOMA-R各指标间存在正相关(r=0.407,r=0.32,r=0.338,r=0.384,r=0.524;P<0.01,P<0.05,P<0.05,P<0.05,P<0.01)。结论:NASH患儿存在着血脂升高、高胰岛素和高瘦素血症,瘦素抵抗与胰岛素抵抗单独或共同构成NASH的发病因素之一。Objective： To explore the relationship between nonalcoholic steatohepatitis in obese children and insulin and leptin resistence.Methods： Serum levels of ALT,free fatty acid（FFA）,triglyceride（TG）,insulin and leptin were assayed in obese children from June 2008 to April 2010,23 of them were diagnosed as NASH,17 with neither abnormal hepatic sonograms nor elevated ALT were divide into OB group and 20 normal children into control group.The correlation of plasma ALT with FFA,TG,insulin,leptin and HOMA-R was analyzed.Results： The levels of plasma FFA,TG,insulin and leptin were increased in NASH children,as compared with theose in OB group and control group（P0.05）.ALT was correlated well with FFA,TG,insulin,leptin and HOMA-R（r=0.407,r=0.32,r=0.338,r=0.384,r=0.524,P0.01,P0.05,P0.05,P0.05,P0.01）.Conclusion： The leptin and insulin resistence and elevated blood lipid may be involved in the mechanism of NASH.

关 键 词：非酒精性脂肪肝炎 胰岛素 瘦素 儿童 

分 类 号：R725.8[医药卫生—儿科]