透析前慢性肾脏病患者的微炎症状态与心血管风险  

The Microinflammatory Status and Cardiovascular Risk in the Pre-dialysis Chronic Kidney Disease Patients

作　　者：李素蘋[1,2] 金珍木[1,2] 马飞驹[1,2] 郑约楠[1,2] 陈辉[1,2] 张一帆[1,2] 刘琦[1,2] 胡小明[1,2] 江其泓[1,2] 邵国建[1,2] 

机构地区：[1]温州市第二人民医院 [2]温州医学院病理临床学院肾内科,浙江温州325000

出　　处：《中国现代医生》2011年第11期19-20,共2页China Modern Doctor

基　　金：浙江省温州市科技计划项目;项目编号:Y20080191

摘　　要：目的了解GFR(15～59)mL/(min.1.73m2)的CKD患者微炎症状态的发生率。方法观察CKDⅢ～Ⅳ期患者36例,与29例健康对照者以及32例ESRD患者比较,分析其炎症指标血白介素-6(IL-6)、肿瘤坏死因子α(TNF-α)、同型半胱氨酸(Hcy)、超敏C反应蛋白(hsCRP)。结果 CKDⅢ～Ⅳ期的患者与ESRD患者的IL-6、TNF-α、Hcy、hsCRP均较正常人群偏高(P<0.05)。结论在CKDⅢ～Ⅳ期患者中已经普遍存在微炎症状态。Objective To investigate the morbidity of microinflammatory status in pre-dialysis chronic kidney disease patients. Methods 97 cases were enrolled,classified as three groups：group 1：36 patients in CKD stage Ⅲ-Ⅳ;group 2：29 healthy controlled patients;group 3：32 end stage renal disease patients without dialysis. We performed interleukin-6,Tumor necrosis factor-alpha,homocysteine and high-sensitivity C-reactive protein to evaluate microinflammatory status. Results Compared to the healthy group,the CKD patients in stage Ⅲ-Ⅳ showed higher IL-6,TNF-α ,Hcy,hsCRP as well as the ESRD patients（P〈0.05）,there was no difference between those two groups except the ESRD patients showed the most higher Hcy and hs-CRP levels （P〈0.05）. Conclusion Microin- flammatory status is really present in chronic kidney disease stage Ⅲ-Ⅳ patients.

关 键 词：慢性肾脏病 微炎症状态 白介素-6 肿瘤坏死因子 同型半胱氨酸 超敏C反应蛋白 

分 类 号：R692.5[医药卫生—泌尿科学]