自拟疏肝化瘀汤治疗无结石性慢性胆囊炎的实验研究  

Experimental study of treating acalculous chronic cholecystitis with shugan huayu decoction

作　　者：刘翔[1] 刘忠民[2] 章任兵[2] 陶蕾[2] 徐振萍[2] 

机构地区：[1]广东医学院,07级在职研究生524000 [2]深圳市龙岗区人民医院

出　　处：《中国实用医药》2011年第10期41-42,共2页China Practical Medicine

基　　金：深圳市龙岗区科技计划资助项目(项目编号:YL-2009069)

摘　　要：目的研究自拟疏肝化瘀汤对无结石慢性胆囊炎的治疗作用及其作用机制方法在大耳兔体内复制慢性胆囊炎模型,同时以自拟疏肝化瘀汤进行治疗,通过胆囊的病理组织切片来观察治疗效果,通过检测血脂、肝功以及胆汁的胆固醇和胆汁酸含量等初步探讨其作用机制。结果中药组血胆固醇、脂蛋白、转氨酶等指标明显优于模型组(P<0.05)。胆汁TC值:模型组>中药组(P<0.05),中药组>空白组(P<0.05);胆汁TB值:模型组<中药组(P<0.05)。组织学检查显示中药组胆囊炎症反应明显减轻,肝脏病理改变较轻。结论自拟疏肝化瘀汤抑制兔胆囊炎症反应作用明显,其作用机制是因该方具疏肝化瘀﹑消痰散结之功效,从而达到了清血柔肝,消炎利胆的作用。Objective The effect and mechanism of treating acalculous chronic Cholecystitis with self-made ＂Shugan Huayu decoction＂ is investigated.Methods Reconstructed chronic cholecystitis model in big ear rabbits,at the same time treated them with self-made ＂Shugan Huayu decoction＂.Observed therapeutic effect through the pathologic biopsy of gallbladder and discussed on the mechanism of it through testing blood fat,liver function and content of bile cholesterol and bile acid etc.Results Cholesterol,lipoproteins,and aminotransferase levels in serum of Chinese medicine group were obviously better than those of model group（P0.05）.Bile TC（total cholesterol）：model groupChinese medicine group（P0.05）,Chinese medicine grouPcontrol group（P0.05）;Bile TB（total bile acid）：model groupChinese medicine group（P0.05）.The histologic examination showed gallbladder inflammation and liver pathological changes of Chinese medicine group were less than those of model group.Conclusion Self-made ＂Shugan Huayu decoction＂ could prevent rabbit＇s gallbladder inflammatory reaction obviously,its mechanism may be for its function of removing blood stasis and away with phlegm,so as to achieve the effect of soft liver and improving choleresis.

关 键 词：无结石慢性胆囊炎 疏肝化瘀汤 实验研究 

分 类 号：R259[医药卫生—中西医结合]