江苏省一般人群乙型肝炎表面抗原阳性率与乙肝疫苗免疫的关系  

Relationship between seropositive rate of HBsAg and hepatitis B vaccination in general population of Jiangsu province

作　　者：王毓[1] 翟祥军[2] 许卫国[2] 鲍倡俊[2] 朱叶飞[2] 殷晓梅[2] 彭红[2] 朱立国[2] 张婷婷[3] 陈新峰[4] 杜国明[4] 柳丽江 王跃进[5] 宗俊[5] 蒋卫平[5] 姚根红[6] 曹民权[6] 吴淑华[6] 汪华[1] 

机构地区：[1]南京医科大学公共卫生学院流行病与卫生统计学系,江苏南京210029 [2]江苏省疾病预防控制中心,江苏南京210009 [3]东南大学公共卫生学院流行病与卫生统计学系,江苏南京210009 [4]张家港市疾病预防控制中心,江苏张家港215600 [5]丹阳市疾病预防控制中心,江苏丹阳212300 [6]泰兴市疾病预防控制中心,江苏泰兴225400

出　　处：《南京医科大学学报（自然科学版）》2011年第4期532-536,共5页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家科技重大专项(2009ZX10004-904)

摘　　要：目的:调查分析江苏省3个县一般人群乙型肝炎表面抗原阳性率和乙型肝炎疫苗免疫接种史的关系,为采取针对性干预措施,提高乙型肝炎综合防治水平提供依据。方法:采用分地区整群随机抽样方法确定调查对象,开展问卷调查,采集静脉血,检测乙型肝炎表面抗原(HBsAg)。结果:张家港、丹阳和泰兴的HBsAg阳性率按全国人口构成标化后分别为4.61%、6.88%和10.06%,18岁以上计划免疫前出生人群HBsAg阳性率均显著高于18岁以下计划免疫后出生人群。张家港、丹阳和泰兴3个县中18岁以上年龄组接种乙型肝炎疫苗人群的HBsAg阳性率均明显低于未接种乙肝疫苗人群。结论:张家港、丹阳和泰兴的乙型肝炎疫苗纳入儿童计划免疫已显成效,儿童组HBsAg阳性率明显降低,成人乙型肝炎疫苗接种也可获得明显效果,应提高成人疫苗接种率,以期降低该人群HBsAg阳性率。Objective：To analyze the relationship of seropositive rate of HBsAg with hepatitis B vaccination in a randomly selected general population in three counties of Jiangsu province,and improve the comprehensive control against hepatitis B.Methods：With cluster random sampling in different regions,questionnaire survey was conducted and blood samples were collected to detect HBsAg by ELISA.Results：The standardized seropositive rates of HBsAg were 4.61%,6.88% and 10.06% in Zhangjiagang,Danyang and Taixing respectively,and the seropositive rate of HBsAg among people over 18 years old who were born before programmed immunization started was significantly higher than that among people under 18 years old.The hepatatis B vaccine inoculation rates were 39.56%,19.66% and 41.04% in Zhangjiagang,Danyang and Taixing respectively.In the population over 18 years,the seropositive rate of HBsAg among people who were inoculated with hepatitis B vaccine was lower than that among people who hadn＇t been inoculated.Conclusion：The programmed hepatitis B immunization of newborns has got great achievement and hepatitis B vaccine inoculation among adults also obtained notable results.The immunization for the adults with hepatitis B vaccine should be improved to better control the infection of HBV.

关 键 词：乙型肝炎 表面抗原 阳性率 乙型肝炎疫苗 免疫接种 

分 类 号：R512.6[医药卫生—内科学]