微小RNA与免疫调节  

microRNAs:Novel regulators during the immune response

作　　者：王琳[1] 谢青[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院感染科,上海200025

出　　处：《微生物与感染》2011年第1期39-43,共5页Journal of Microbes and Infections

基　　金："十一五"国家科技重大专项(2008ZX10002-005;2008ZX10002-007;2008ZX09312-007);国家自然科学基金(30872252);上海市科委基础研究重点项目(08JC1415300)

摘　　要：微小RNA(miRNA)是一类22核苷酸的高度保守的小分子非编码RNA,主要通过与靶mRNA的3′非编码区碱基互补配对结合而引起靶RNA降解或翻译抑制。越来越多的研究显示,miRNA在免疫反应中具有新型调节作用,包括调节免疫细胞的发育和分化、B细胞抗体的产生、炎性介质的释放、细胞信号转导等。miRNA在维持机体免疫系统的自稳和免疫相关疾病发生中的作用也逐渐受重视。本文综述了miRNA调节固有性和适应性免疫反应功能和机制的研究进展。microRNA（miRNA）,which is an abundant class of 22nt highly conversed,small non-coding RNA,can make mRNA degradation or influence mRNA translation via a complementary binding with the 3＇-UTR of the miRNA.Recently,more studies have shown that the effects of these non-coding small RNAs on immune system development and response,and also that miRNA is involved in the regulation of immunity,including the development and differentiation of immune cells,antibody production,inflammatory mediator release,and signal transduction in cells.miRNA is considered to play a role in maintaining the homeostasis of immune system and in immune-associated diseases.Here,the latest findings are summarized to explore the function and mechanism of miRNA in modulating innate and adaptive immune responses.

关 键 词：微小RNA 免疫反应 调节 

分 类 号：R392.1[医药卫生—免疫学]