两种糖皮质激素注射液皮损内注射治疗活动期斑秃的临床疗效观察  

Intralesional injection of two kinds of glucocorticosteroid for the treatment of active alopecia areata： a comparative study

作　　者：袁晋[1] 吴文育[1] 宋萌萌[1] 傅雯雯[1] 

机构地区：[1]复旦大学附属华山医院皮肤科,上海200040

出　　处：《中华皮肤科杂志》2011年第4期285-287,共3页Chinese Journal of Dermatology

摘　　要：目的 比较复方倍他米松注射液和醋酸曲安奈德注射液皮损内注射治疗活动期斑秃的临床疗效.方法 将160例活动期斑秃患者随机分成两组,治疗组100例、对照组60例,治疗组用复方倍他米松注射液皮损内注射,对照组用醋酸曲安奈德注射液皮损内注射,每3周1次,12周后观察结果.结果 治疗12周后治疗组痊愈60例（60.0%）,显效32例（32.0%）,总有效率92.0%;对照组痊愈25例（41.7%）,显效19例（31.67%）,总有效率73.3%;治疗组有效率和痊愈率显著高于对照组（χ2值分别为10.25和5.06,P〈0.01和〈0.05）.治疗组出现局部头皮萎缩8例（8%）,局部毛囊炎8例（8%）;对照组出现局部头皮萎缩9例（15%）,局部毛囊炎3例（5%）,两组不良反应发生率比较,差异无统计学意义（P〉0.05）.结论 复方倍他米松注射液皮损内注射治疗活动期斑秃疗效显著.Objective To compare the clinical efficacy of intralesional betamethasone versus triamcinolone acetonide acetate in the treatment of active alopecia areata. Methods A total of 160 patients with active alopecia areata were divided into two groups, test group （n = 100） treated with intralesional betamethasone, and control group （n = 60） treated with intralesional triamcinolone acetonide. Both injections were given once every 3 weeks for 12 consecutive weeks. Results After 12-week treatment, the cure rate, response rate, and total response rate were 60.0%, 32.0% and 92.0% in the test group, respectively, compared to 41.7%, 31.67% and 73.3% in the control group, respectively. A significant increase was observed in the cure rate and response rate in the test group compared with the control group （χ2 = 10.25, 5.06, P 〈 0.01 and 0.05）. During the treatment course, 8 （8%） patients in the test group and 9 （15%） patients in the control group developed localized atrophy of the scalp; 8 （8%） patients in the test group and 3 （5%） patients in the control group developed localized folliculitis; no significant difference was observed between the two groups in the occurrence of adverse reactions （P〉 0.05）. Conclusion Intralesional use of compound betamethasone injection has a notable therapeutic effect on alopecia areata.

关 键 词：醋酸曲安奈德注射液 皮损内注射 注射治疗 疗效观察 临床疗效 活动期 糖皮质激素 复方倍他米松注射液 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]