原发不孕患者行短时受精和half-ICSI结果的比较  

Comparative Analysis on the Outcome of Short Time Insemination and half-ICSI for Female Primary Infertility

作　　者：孔风云[1] 管群[1] 张琪瑶[1] 菅福琴[1] 孙伟[1] 

机构地区：[1]山东中医药大学第二附属医院生殖医学中心,济南250001

出　　处：《生殖与避孕》2011年第3期196-199,204,共5页Reproduction and Contraception

基　　金：山东省中医药科技发展计划普通项目(2009-150)

摘　　要：目的:探讨女性原发不孕患者行短时受精和half-ICSI 2种受精方式对受精率和胚胎发育潜能的影响。方法:回顾性分析175个周期女性原发不孕患者体外助孕资料,分为短时受精和/或联合早期补救ICSI周期组(A组,114个周期,其中A1组103个短时IVF受精周期,A2组11个早期补救ICSI周期)及half-ICSI周期组(B组,61个周期),分析比较各组IVF/ICSI-ET结局。结果:B组较A组不孕年限长,获卵数多,正常受精率低,差异有统计学意义(P<0.05)。但异常受精率、优质胚胎率和临床妊娠率差异无统计学意义(P>0.05)。A1组正常受精率明显低于A2组(P<0.05),异常受精率、优质胚胎率和临床妊娠率组间差异无统计学意义(P>0.05)。不同病因对A、B组患者的妊娠结局无显著影响。结论:短时受精和/或联合早期补救ICSI对原发不孕患者是一种较为合理而安全的受精方式。Objective： To explore the effects of short time insemination and half-ICSI on the fertility rate and embryonic development potentiality among female primary infertility.Methods： In a retrospective study,the assisted gestation information of 175 cycles among female primary infertility patients was categorized as follows： group A（short time insemination and/or immediate rescue ICSI,n=114） including group A1（short time insemination,n=103） and group A2（immediate rescue ICSI,n=11）;group B（half-ICSI,n=61）.The outcomes of IVF/ICSI-ET were compared.Results： Compared with group A,the infertility time was longer,the number of oocytes was higher and the fertility rate was obviously lower in group B（P0.05）.The differences of abnormal fertility rate,the ratio of good embryos and pregnancy rate between group A and group B were not statistically significant（P0.05）.The fertility rate in group A1 was obviously lower than that in group A2（P0.05）,although the differences of abnormal fertility rate,good embryos ratio and pregnancy rate showed no statistical significance between the groups A1 and A2.Different etiological factors had no statistical effects on gestation results.Conclusion： The method,which short time insemination and immediate rescue ICSI are combined,is more feasible and safe for female primary infertility.

关 键 词：受精方式 短时受精 卵胞浆内单精子注射(ICSI) 临床妊娠率 

分 类 号：R711.6[医药卫生—妇产科学] R714.8[医药卫生—临床医学]