老年急性心肌梗死患者B型利钠肽和超敏C反应蛋白检测分析  

Clinical significance of determination of the serum levels of brain （B-type） natriuretic peptide and high-sensitivity C-reactive protein in elderly patients with acute myocardial infarction

作　　者：王新鸣[1] 厉伟民[1] 卢亮[1] 李国洪[1] 

机构地区：[1]温州医学院附属东阳医院浙江省东阳市人民医院心内科,东阳322100

出　　处：《中华老年医学杂志》2011年第4期282-284,共3页Chinese Journal of Geriatrics

摘　　要：目的 探讨B型利钠肽（BNP）和超敏C反应蛋白（hs-CRP）在急性心肌梗死（AMI）检测中的价值.方法 回顾性分析60例AMI患者和50例健康者的资料,观察BNP和hs-CRP在AMI和Killip分级中的表达特征,并探讨其与预后的关系.结果 治疗前AMI组的BNP、hs-CRP和肌酸激酶同工酶（CK-MB）与对照组比较差异均有统计学意义（P＜0.05）,AMI组治疗前后比较差异有统计学意义（P＜0.05）.治疗前后BNP、hs-CRP与CK-MB呈正相关（r=0.892,r=0.683,均P＜0.05）.BNP、hs-CRP和CK-MB水平随Killip分级的严重程度而升高,呈正相关.BNP、hs-CRP和CK-MB各级别比较差异有统计学意义（P＜0.01）.60例中,8例（13.3%）死亡,单因素分析结果显示BNP（≥56.1 pmol/L）、hs-CRP（≥9.0 mg/L）、CK-MB（≥75.1 U/L）和Killip分级Ⅲ、Ⅳ级为AMI患者预后的不良因素（均P＜0.05）.结论 BNP和hs-CRP为AMI较为敏感的生化指标,其检测对于AMI的诊断、病情评估及预后具有重要价值.Objective To explore the clinical significance of determination of the serum levels of brain （B-type） natriuretic peptide （BNP） and high-sensitivity C-reactive protein （hs-CRP） in patients with acute myocardial infarction （AMI）.Methods The clinical data of 60 cases with AMI and 50healthy controls were analyzed retrospectively.The BNP and hs-CRP levels were analyzed in AMI and Killip class,and their relationship with prognosis was investigated.Results The serum levels of BNP,hs-CRP and creatine kinase （CK）-MB） were higher in AMI group than in control group （all P〈0.05）,and the levels were lowered after treatment （P〈0.05）.The correlation analysis indicated that BNP and hs-CRP had positive correlations with CK-MB （r=0.892 and 0.683,all P〈0.05）,and increased along with the severity of Killip classification.The 8 cases （13.3 % ） died,and single factor analysis revealed that BNP （≥56.1 pmol/L）,hs-CRP （≥9.0 mg/L）,CK-MB （≥75.1 U/L） and Killip classification （grade Ⅲ and Ⅳ） were the poor prognostic factors （P〈0.05）.Conclusions The elevation of BNP and hs-CRP level is correlated with the severity of AMI,and could be used to evaluate the AMI patients＇ diagnosis and prognosis.

关 键 词：利钠肽 脑 C反应蛋白 心肌梗死 预后 

分 类 号：R542.22[医药卫生—心血管疾病]