2型糖尿病合并胆囊结石的相关危险因素  

Clinical analysis of risk factors for type 2 diabetes mellitus complicated with gallstone disease

作　　者：于岚[1] 何小东[1] 武峤[1] 刘卫[1] 洪涛[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院基本外科,100730

出　　处：《中华消化外科杂志》2011年第2期110-112,共3页Chinese Journal of Digestive Surgery

基　　金：北京市重点学科建设项目（HK100230446）

摘　　要：目的 探讨2型糖尿病患者发生胆囊结石的相关危险因素.方法 回顾性分析2007年1月至2010年5月北京协和医院体检中心2574例2型糖尿病患者的临床资料,对其中429例2型糖尿病合并胆囊结石患者（研究组）和2145例2型糖尿病不合并胆囊结石患者（对照组）,按照年龄、性别进行1∶5配比以进行病例对照研究.计数资料采用x2检验,对收缩压（SBP）、舒张压（DBP）、空腹血糖（FBG）、TC、TG、高密度脂蛋白胆固醇（HDL-CH）、低密度脂蛋白胆固醇（LDL-CH）和体质指数（BMI）等相关危险因素进行单因素分析,采用四格表x2检验筛选出有统计学意义的可疑危险因素,再对这些可疑因素进行多因素Logistic回归分析.结果 单因素分析结果显示在SBP、FBG、TC、HDL-CH及BMI 5个方面,研究组与对照组比较,差异有统计学意义（x2=20.323,4.365,4.028,7.049,7.319,P＜0.05）.去除年龄、性别的影响后,多因素分析结果证实SBP、TC、HDL-CH及BMI是2型糖尿病合并胆囊结石患者的危险因素（x2=18.047,6.905,12.884,7.557,P＜0.05）.结论 BMI、SBP和TC水平增高及HDL-CH浓度降低可能是2型糖尿病合并胆囊结石的危险因素.Objective To explore risk factors for type 2 diabetes mellitus complicated with gallstone disease. Methods The clinical data of 429 type 2 diabetes mellitus patients complicated with gallstone disease （case group） and 2145 type 2 diabetes mellitus patients without gallstone disease （control group） were collected from the Health Center of Peking Union Medical College Hospital from January 2007 to May 2010. According to sure （SBP）, diastolic blood pressnre （DBP）, fasting blood glucose （FBG）, total cholesterol （TC）, Triglyceride （TG）, high-density lipoprotein cholesterol （HDL-CH）, low-density lipoprotein cholesterol （LDL-CH） and body mass index （BMI） were statistically analyzed by fourfold table chi-square test or conditional Logistic regression.Results Univariate analysis showed that there was a significant difference in the levels of SBP, FBG, TC, HDL-CH and BMI between the case group and the control group （x2 =20.323, 4.365, 4.028, 7.049, 7.319, P＜0.05）. Multivariate analysis confirmed that SBP, TC, HDL-CH and BMI were risk factors for gallstone disease in patients with type 2 diabetes mellitus （x2 = 18. 047, 6. 905, 12. 884, 7. 557, P ＜ 0. 05）. Conclusion Increased SBP, TC and BMI and decreased HDL-CH may be the risk factors for type 2 diabetes mellitus complicated with gallstone disease.

关 键 词：2型糖尿病 胆囊结石 危险因素 

分 类 号：R587.1[医药卫生—内分泌]