睡眠呼吸暂停综合征患者炎症和血管活性因子水平与合并高血压的关系  

Association of inflammation and vascular active factors with hypertension in obstructive sleep apnea syndrome patients

作　　者：钱小顺[1] 李天志[1] 康春燕[1] 孙宝君[1] 刘长庭[1] 

机构地区：[1]解放军总医院南楼临床部呼吸内科,北京100853

出　　处：《中华老年多器官疾病杂志》2011年第1期15-17,共3页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：解放军总医院苗圃基金(06MP50)~~

摘　　要：目的观察阻塞性睡眠呼吸暂停综合征(OSAS)患者炎症、血管活性因子水平变化与合并高血压的关系。方法用多导睡眠仪检查确诊重度OSAS患者70例,其中30例为单纯OSAS患者,40例合并高血压病。同时以30例年龄相近无OSAS和高血压的健康男性做为对照组。用ELISA、放射免疫法和全自动生化仪检测所有纳入对象血清高密度脂蛋白胆固醇(HDL-C)、血清低密度脂蛋白胆固醇(LDL-C)、C反应蛋白、去甲肾上腺素(NA)、一氧化氮(NO)、血浆血管紧张素Ⅱ(AngⅡ)和内皮素(ET)的水平。结果 OSAS合并高血压组多有高血压病家族史,合并糖尿病较单纯OSAS组多。血清HDL-C水平较单纯OSAS组低(P<0.05)、而LDL-C水平较单纯OSAS组高(P<0.05)。OSAS合并高血压患者血清CRP、NA、A ngⅡ和ET均较单纯OSAS患者明显升高(P<0.05),但OSAS合并高血压患者NO水平低于单纯OSAS患者(P<0.01)。结论炎症和血管活性因子可能在OSAS患者合并高血压的发生发展中起一定的作用。Objective To observe the association of inflammation and vascular active factors with hypertension in obstructive sleep apnea syndrome （OSAS）patients. Methods Diagnosis of OSAS was confirmed with polysomnography （PSG） in 70 patients, among them, 40 patients were complicated with hypertension. Another 30 age-matched healthy males were taken as normal controls. The serum levels of high-density lipoprotein cholesterol （HDL-C）, low-density lipoprotein cholesterol （LDL-C）, C-reactive protein （CRP）, noradrenalin （NA）, angiotensin Ⅱ （Ang Ⅱ ）, endothelin （ET） and nitric oxide （NO） were measured with ELISA, radioimmuno-assay, and auto biochemical assay respectively. Results Hypertension-complicated OSAS patients had a family history of hypertension. There were more patients complicated with diabetes in OSAS patients with hypertension than in those without hypertension. Serum HDL-C was lower（P〈0.05）, but LDL-C was higher in patients with hypertension than those without hypertension（P〈0.05）. Age, body mass index, Epworth sleepiness scale score, respiratory disturbance index, apnea time and oxygen saturation were not different significantly between patients with and without hypertension. Serum levels of CRP, NA, Ang Ⅱand ET were higher in patients with hypertension than those without hypertension（P〈0.05）, but NO level was lower in OSAS patients with hypertension（P〈0.01）. Conclusion Endothelial impairment and chronic inflammation may play a role in the development of hypertension in OSAS patients.

关 键 词：睡眠呼吸暂停综合征 炎症 内皮 创伤和损伤 高血压 

分 类 号：R563[医药卫生—呼吸系统]