Preparation and Characterization of Chitosan/β-GP Membranes for Guided Bone Regeneration  

作　　者：崔军 徐欣 孙康宁 

机构地区：[1]Department of Dental Implant Center,School of Stomatology,Shandong University [2]Shandong Provincial Key Lab Dral Biomedicine [3]School of Materials Science and Engineering,Shandong University

出　　处：《Journal of Wuhan University of Technology(Materials Science)》2011年第2期242-246,共5页武汉理工大学学报（材料科学英文版）

基　　金：Funded by the National Natural Science Foundation of China(No.30870610);the National Glycoengineering Research Center,ShandongUniversity (No.NGRC2009F02);the Shandong Provincial Natural ScienceFoundation (No. Y2008C107)

摘　　要：Bioabsorbable chitosan/β-glycerol phosphate （CS/β-GP） composite membranes were fabricated through a relatively PH neutral and mild sol-gel process for guided bone regeneration （GBR）.Their structural properties,morphology,and tensile strength were investigated.FTIR and XRD analyses indicated that there were chemical bonds between the CS andβ-GP.SEM analysis revealed that the CS/β-GP composite membranes had a porous structure both at the surface and in sublayers.Even though the incorporation ofβ-GP in the CS matrix decreased the initial tensile strength of the membrane,the CS/β-GP membranes were still fit for GBR application with their tensile strength of roughly 1MPa.The concentration ofβ-GP was proportional to the pore size and thickness but was inversely proportional to the tensile strength of the CS/β-GP membrane.The present findings indicate that,based on its characteristics,the CS/β-GP composite membrane is a potential bioresorbable membrane for use in guided bone regeneration.Bioabsorbable chitosan/β-glycerol phosphate （CS/β-GP） composite membranes were fabricated through a relatively PH neutral and mild sol-gel process for guided bone regeneration （GBR）.Their structural properties,morphology,and tensile strength were investigated.FTIR and XRD analyses indicated that there were chemical bonds between the CS andβ-GP.SEM analysis revealed that the CS/β-GP composite membranes had a porous structure both at the surface and in sublayers.Even though the incorporation ofβ-GP in the CS matrix decreased the initial tensile strength of the membrane,the CS/β-GP membranes were still fit for GBR application with their tensile strength of roughly 1MPa.The concentration ofβ-GP was proportional to the pore size and thickness but was inversely proportional to the tensile strength of the CS/β-GP membrane.The present findings indicate that,based on its characteristics,the CS/β-GP composite membrane is a potential bioresorbable membrane for use in guided bone regeneration.

关 键 词：CHITOSAN β-glycerol phosphate guided bone regeneration MEMBRANE thermo-sensitive hydrogel 

分 类 号：R318.0[医药卫生—生物医学工程] R783[医药卫生—基础医学]