RNA编辑功能和RNA干扰  

Functions of RNA Editing and RNA Interference

作　　者：代鹏[1] 沈辉[1] 马军武[1] 刘光远[1] 

机构地区：[1]中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室农业部畜禽病毒学重点开放实验室农业部兽医公共卫生重点开放实验室,兰州730046

出　　处：《生物技术通报》2011年第5期21-25,共5页Biotechnology Bulletin

摘　　要：RNA编辑被认为是生命体一种新的基因加工与修饰现象,是指DNA转录成RNA后除RNA剪切外的其他加工过程,以核苷酸的删除、插入或替换等方式改变遗传信息,揭示生物进化过程中基因修饰和调控的另一个重要途径,是对中心法则的重要补充。而RNAi是一种由dsRNA介导的,在转录水平、转录后水平和翻译水平上阻断基因表达的基因调节途径。着重介绍RNA编辑功能、RNA编辑与RNA干扰关系。RNA editing is defined as a new phenomenon of gene process and modification in the living organisms,including nucleotide insertion/deletion or replaces to change gene-encoded sequence information at the RNA level,excluding RNA splicing.RNA editing reveals another important pathway of gene modification and regulation,and is the significant complement of Central Dogma.While RNA interference is a gene regulate pathway of blocking gene expression,triggered by double-stranded RNA at the level of transcription,post-transcription and translation.Introduced the functions of RNA editing and the relationship between RNA editing and RNA interference.

关 键 词：RNA编辑 功能 插入/删除 替换 RNA干扰 

分 类 号：Q522[生物学—生物化学]