不同糖耐量个体氧化应激水平与胰岛β细胞第一时相分泌功能的关系  

Relationship between oxidative stress and the first-phase of glucose-stimulated insulin secretion from pancreatic β cell in individuals with different glucose tolerance

作　　者：李永玲[1] 邓华聪[1] 糜公仆[1] 秦登优[1] 龙健[1] 冯正平[1] 

机构地区：[1]重庆医科大学附属第一医院内分泌科,400016

出　　处：《中华内分泌代谢杂志》2011年第3期210-212,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81070639,30771038,30370670）;教育部重点项目（KJ050314）;教育部博士点专项科研基金（20050631009）;教育部第二批“春晖计划”资助项目

摘　　要：探讨不同糖耐量个体氧化应激与β细胞第一时相分泌功能的关系.比较各组8-羟基脱氧尿苷（8-OHdG）、丙二醛、超氧化物歧化酶（SOD）、脂联素、0～10 min胰岛素曲线下面积（AUC）、急性胰岛素反应（AIR3-5）等指标.发现随病情发展,氧化应激指标水平升高,抗氧化酶活性、脂联素及β细胞第一时相分泌功能下降,丙二醛、8-OHdG与脂联素、稳态模型评估的胰岛β细胞功能指数（HOMA-β）、AUC、AIR3-5负相关,SOD与脂联素、HOMA-β、AUC、AIR3-5正相关,8-OHdG、SOD是AIR3-5的独立相关因素.氧化应激对β细胞第一时相分泌功能有显著影响,可能与2型糖尿病的发病机制密切相关.The relationship between oxidative stress and the first-phase of pancreatic β cell insulin secretion in subjects with different statuses of glucose tolerance was explored. Fasting adiponectin, 8-hydroxydeoxyguanosin （ 8-OHdG）, malondialdehyde （ MDA ）, superoxide dismutase （ SOD ）, insulin area under the curve （ AUC ） from 0 to 10 min, and AIR3-5 were measured. The levels of oxidative stress-related markers were elevated, the activities of superoxide dismutase,adiponectin, and first-phase of insulin secretion were reduced with the disease progression. MDA and 8-OHdG were negatively correlated with adiponectin, homeostasis model assessment β cell function index （ HOMA-β ）,AUC ,and AIR3-5. SOD was positively correlated with adiponectin, HOMA-β, AUC, AIR3-5. The plasma 8-OHdG and SOD were independently associated with AIR3-5. Oxidative stress exerts a significant effect on the first phase of pancreatic β cell insulin secretion, which may contribute to the pathogenesis of type 2 diabetes.

关 键 词：糖尿病 2型 静脉葡萄糖耐量试验 第一时相胰岛素分泌 氧化应激 脂联素 

分 类 号：R587.1[医药卫生—内分泌]