钾及钾通道在免疫中的作用  

Roles of potassium and potassium channel in immunity

作　　者：彭芬芬[1] 阳晓[2] 李赟[1] 余学清[2] 

机构地区：[1]江西省人民医院肾内科,南昌330006 [2]中山大学附属第一医院肾内科,广州510080

出　　处：《免疫学杂志》2011年第4期342-345,共4页Immunological Journal

摘　　要：钾离子是机体内环境的最重要的阳离子之一,钾通道是钾离子转移至细胞外的主要途径,此二者不仅参与维持机体生理功能的作用,而且对机体免疫亦有调节作用。钾离子和钾通道参与了多种免疫细胞的活化及细胞的凋亡。在T细胞介导的自身免疫性疾病中,钾通道表达异常,选择性阻滞钾通道可以减缓疾病的发生发展。电压门控性钾通道已经成为治疗自身免疫性疾病的新靶点。The potassium ion is one of most important cation in homeostasis of organism.The potassium channel is the main way by which potassium ions transport from inside of cells to outside of cells.Potassium ion and potassium channel can not only maintain the physiological function,but also regulate the immune.They are also involved in cell apoptosis and activation of varieties of immune cells.Potassium channel expression is abnormal in T cell-mediated autoimmune disease and selective blocking of potassium channel could prevent the disease aggravation.Thus voltage-gated potassium channel has been the new target for the treatment of autoimmune disease.

关 键 词：钾 钾通道 免疫细胞 自身免疫性疾病 

分 类 号：R593.2[医药卫生—内科学]