复合磷霉素多孔生物陶瓷的制备及其理化性能  

Preparation and performance of fosfomycin-i mpregnated bioceramic

作　　者：陈文钧[1] 许耀[1] 卢建熙 周则红 马晓生[1] 姜建元[1] 

机构地区：[1]复旦大学附属华山医院骨科,上海200040 [2]上海贝奥路生物材料有限公司,上海200035

出　　处：《复旦学报（医学版）》2011年第2期152-154,共3页Fudan University Journal of Medical Sciences

基　　金：上海市卫生局局级科研项目(2006-9)

摘　　要：目的研制磷霉素多孔生物陶瓷复合体,为临床植骨并减少感染发生提供更好的选择。方法将磷霉素溶液与多孔生物陶瓷浸泡,风干。测定生物陶瓷吸附磷霉素能力以及测定吸附后多孔生物陶瓷理化性能上的变化。结果生物陶瓷吸附一定量的磷霉素后,理化性能测试提示其钙磷比和压缩强度仍在正常范围内。结论生物陶瓷能吸附磷霉素,其理化性质吸附前后没有明显的变化。Objective To prepare fosfomycin-impregnated bioceramic as a new kind of bone graft. Methods The fosfomycin-impregnated bioceramic was prepared by means of impregnation.After irrigation sterilization,the physical and mechanical properties of fosfomycin-impregnated bioceramic was investigated. Results The physical and mechanical property test showed that the compressive strength was in the normal range after fosfomycin loaded. Conclusions There was no significant differents after the fosfomycin-impregnated bioceramic was prepared.

关 键 词：多孔生物陶瓷 磷霉素 复合体 

分 类 号：R331[医药卫生—人体生理学]