肌成纤维细胞在支气管哮喘气道结构重塑中的作用  

Role of myofribroblast in airway remodeling in bronchial asthma

作　　者：胥武剑[1] 吴琳[1] 李强[1] 

机构地区：[1]第二军医大学附属长海医院呼吸内科,上海200433

出　　处：《中华哮喘杂志（电子版）》2011年第1期55-58,共4页Chinese Journal of Asthma(Electronic Version)

摘　　要：肌成纤维细胞兼具成纤维细胞和平滑肌细胞的某些特征,来源于局部细胞的增殖,其他细胞的转化及循环中前体细胞的定植,在疤痕形成、肺纤维化等病理过程中发挥重要作用。研究显示其受支气管哮喘相关炎症因子及介质的调控,通过分泌细胞外基质及迁移功能而参与支气管哮喘气道重塑。深入了解肌成纤维细胞在支气管哮喘气道重塑中的作用有助于建立防治气道重塑的新策略。Myofibroblast is a kind of fibroblast-like cell which shares common features of fibroblast and smooth muscle cells. It has a very heterogenous origin and plays a critical role in scar formation and lung fibrosis. Evidence showed that myofibroblast was regulated by bronchial asthma related cytokines and exerts its role in asthmatic airway remodeling through secreting extracellular matrix and migration. Further investigation is needed to figure out its role in asthmatic airway remodeling, which may of great help to set up new strategies to prevent this pathophysilogical process.

关 键 词：肌成纤维细胞 哮喘 气道重塑 

分 类 号：R619.6[医药卫生—外科学]