骨碎补治疗去卵巢大鼠骨质疏松的实验研究  

Treatment Effect of Drynaria Total Flavonoids on Ovariectomized Osteoporosis Rats

作　　者：李展春[1] 程光齐[1] 臧危平[1] 刘祖德[1] 

机构地区：[1]上海交通大学医院医学院附属仁济医院骨科,上海200127

出　　处：《中国中医骨伤科杂志》2011年第4期9-11,共3页Chinese Journal of Traditional Medical Traumatology & Orthopedics

摘　　要：目的:观察骨碎补对去卵巢后骨质疏松大鼠骨密度、微结构和生物力学性能的影响,研究骨碎补对治疗骨质疏松的作用。方法:30只6月龄SD大鼠随机分为3组:去卵巢组(OVX)、假手术组(SHAM)和骨碎补治疗组(OVX+D)。骨碎补治疗3个月后,检测各组大鼠的骨密度、微结构、生物力学性能的变化,并比较各组间差异。结果:OVX+D组的的骨密度、微结构、生物力学指标与OVX组比较差异有统计学意义,与SHAM组比较差异无统计学意义。结论:骨碎补可以增加去卵巢后骨质疏松大鼠的骨密度,改善微结构,提高生物力学性能,对实验动物的骨质疏松有治疗作用。Objective：To investigate the effects of Drynaria total flavonoids on influence of bone mineral density（BMD）,microstructure,and biomechanics property of the ovariectomized osteoporosis rats.Methods： Thirty female virgin Sprague-Dawley rats,about 6 months old,were randomly divided into 3 group： ovariectomy group（OVX）,sham group（SHAM）,and ovariectomy with Drynaria total flavonoids treatment group（OVX＋D）.All the rats were killed 3 months after treatment.Then the BMD,microstructure,and biomechanics property were compared in each group.Results：The BMD,microstructure,and biomechanics property in OVX＋D group were significant different to OVX group,however,there was no significant difference to SHAM group Conclusion：The Drynaria total flavonoids are effective to treat ovariectomized osteoporosis rats for its function of increasing the bone mineral density and biomechanics property,and improvement the bone microstructure.

关 键 词：骨碎补 去卵巢 骨质疏松 骨密度 微结构 生物力学 

分 类 号：R285.5[医药卫生—中药学]