多西环素及维A酸霜与两者联合使用治疗酒渣鼻的疗效比较研究  

Comparing the therapeutic effect of oral doxycycline,topical tretinoin and their combination therapy in treatment of rosacea

作　　者：赖劲东 杨娟[1] 

机构地区：[1]遂宁市第一人民医院皮肤科,四川遂宁629000

出　　处：《中国美容医学》2011年第3期450-452,共3页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨比较口服多西环素、外用维A酸霜以及两者联合使用治疗酒渣鼻的疗效和安全性。方法:将就诊于我院的酒渣鼻患者共60名,随机分为三组:口服多西环素治疗组、外用维A酸霜治疗组及两者联合治疗组,观察比较三组治疗前后炎症损害数目、红斑评分、毛细血管扩张严重程度的变化情况。结果:治疗12周后,联合治疗组的疗效优于另外两组(P<0.05),而多西环素组与维A酸组的疗效相当(P>0.05),三组中仅发生5例短暂轻微的副作用。结论:多西环素和维A酸外用制剂治疗酒渣鼻均能达到很好的疗效,发生的副作用轻微且短暂,两者联合应用的疗效更为显著,但均无改善毛细血管扩张症状的作用。Objective To evaluate the therapeutic effect and security of oral doxycycline,topical tretinoin and their combination therapy in treatment of rosacea.Methods 60 patients who suffered rosacea were randomly divided into three groups：the oral Doxycycline treatment group,topical tretinoin cream treatment group and their combination treatment group.We compared the changes in the number of inflammatory lesions,erythema scores and the severity of telangiectasia before and after the treatment.Results After 12 weeks of treatment,we found that the therapeutic effect of combination group was better than the other two groups（P0.05）,and a considerable therapeutic effect was achieved in both doxycycline group and tretinoin group（P0.05）.there were only 5 cases involved in transient and minor adverse effect.Conclusions Excellent therapeutic effect with mild and transient adverse could be achieved by oral doxycycline and topical tretinoin,and their combination therapy was better,but they had no improvement in telangiectasia.

关 键 词：酒渣鼻 多西环素 维A酸 药物治疗 

分 类 号：R758.734[医药卫生—皮肤病学与性病学]