用于肿瘤成像的半乳糖/酞菁近红外荧光探针  

Galactose Substituted Phthalocyanines for Tumor Imaging as Near-infrared Fluorescence Probe

作　　者：吕丰[1] 李艳周[1] 武莉[1] 刘天军[1] 

机构地区：[1]中国医学科学院北京协和医学院生物医学工程研究所,天津生物医学材料重点实验室,天津300192

出　　处：《高等学校化学学报》2011年第5期1010-1012,共3页Chemical Journal of Chinese Universities

基　　金：国家“九七三”计划项目(批准号:2006CB705703);国家重大科学研究计划项目(批准号:2006CB933202);教育部博士学科点基金(批准号:20070023020,20101106120052)资助

摘　　要：相对于正电子发射成像（PET）、计算机断面成像（CT）、单光子发射计算机断面成像（SPECT）以及核磁共振成像（MRI）等成像模式而言,光学成像具有无辐射、低成本的特点,尤其是近红外荧光成像可以部分实现对深层组织和器官的探测和成像,在分子成像方面具有特定的优势.分子影像的核心是分子探针,主要面临的问题包括深层次光的传输和采集以及分子探针的发光量子效率、良好的生物相容性和靶向性.针对在体光学成像对分子探针的基本要求设计具有强近红外荧光发光特性、Near-infrared fluorescence imaging can be used in deep tissues and organs for detecting and imaging in biological tissue.It provides effective methods of tumor detecting and tracking the diseases treatments.In order to develop tumor special probe and improve diagnose effect,phthalocyanine conjugation with galactose was synthesized as near-infrared fluorescent probes.The probe had good water-solubility and high emission ability in near-infrared region.In vivo fluorescence imaging effect and organ distribution of probe were conducted with nude mice bearing liver cancer as model.The results show that galactose modified phthalocyanine has obvious near-infrared imaging effect in vivo and a certain tumor targeting ability.So the near-infrared optical probe can be potentially applied in the diagnosis of cancer in future.

关 键 词：近红外荧光探针 半乳糖 酞菁 肿瘤成像 

分 类 号：O621.22[理学—有机化学]