比阿培南在血液科患者临床应用的有效性与安全性研究  

Clinical efficacy and safety of applying biapenem in hematology patients

作　　者：郭智[1] 陈惠仁[1] 何学鹏[1] 杨凯[1] 陈鹏[1] 刘兵[1] 王丙然[1] 刘晓东[1] 

机构地区：[1]北京军区总医院血液科,北京100700

出　　处：《中华医院感染学杂志》2011年第10期2079-2081,共3页Chinese Journal of Nosocomiology

摘　　要：目的评价比阿培南临床应用的有效性和安全性。方法医院血液科中重度感染患者120例,随机分为治疗组（比阿培南组）60例和对照组（美罗培南组）60例,治疗组比阿培南0.3~0.6 g,静注2次/d,对照组美罗培南1 g静注,2~3次/d,疗程一般为7~14 d,观察两组患者用药后感染的临床疗效及不良反应。结果治疗组、对照组的临床总有效率分别为76.7%和78.3%,治疗后细菌清除率分别为90.5%和91.7%,不良反应发生率均为6.7%,两组比较差异均无统计学意义。结论比阿培南是治疗中重度感染的一种安全有效的药物。OBJECTIVE To evaluate the clinical efficacy and safety of applying of biapenem.METHODS A total of 120 patients with severe infection in department of hematology of the general hospital in beijing area were randomly divided into treatment groups（biapenem group） 60 cases and the control group（meropenem group） 60 cases 0.3-0.6g biapenem was used treatment group for 2 times a day intravenously,control group of meropenem 1g intravenously 2 to 3 times a day,treatment was generally 7 to 14 days,the the efficacy and adverse reactions of infection were observed after treatment.RESULTS The treatment group and control group clinical total effective rate was 76.7% and 78.3%,after treatment,bacterial eradication rates were 90.5% and 91.7%,the incidence rate of adverse reactions was 6.7%.No significant difference between the two groups were found.CONCLUSION Biapenem is a safe and effective drug in the treatment of hematological′s moderate to severe infection.

关 键 词：比阿培南 美罗培南 临床应用 有效性 安全性 

分 类 号：R978.1[医药卫生—药品]