慢性乙型肝炎患者聚乙二醇干扰素疗效与血清铁蛋白的相关性研究  

The relationship between efficacy of PEG-interferon and gerum ferritin in the patients with chronic hepatitis B

作　　者：王晓彬[1] 马宝凤[1] 

机构地区：[1]山东省青岛市传染病医院,266033

出　　处：《中国医疗前沿》2011年第6期52-53,共2页China Healthcare Innovation

摘　　要：目的探讨慢性乙型肝炎患者聚乙二醇干扰素疗效与血清铁蛋白变化的关系。方法观察50例聚乙二醇干扰素治疗的乙型肝炎患者临床疗效,同时测其血清铁蛋白水平。结果血清铁蛋白的增高与肝脏病变的严重程度呈正比。在聚乙二醇干扰素治疗的50例患者中,血清铁蛋白水平<400ng/ml者疗效明显优于400ng/ml以上者(P<0.005),提示血清铁蛋白水平增高使患者对聚乙二醇干扰素的反应降低。在有治疗反应的25例患者中,持续应答者与暂时应答者血清铁蛋白均值差异有显著意义(P<0.005)。结论血清铁蛋白水平较高可能降低对干扰素治疗的反应性且使疗效不稳定。Objective To study the relationship between efficacy of PEG-interferon and gerum ferritin in the patients with chronic hepatitis B.Methods Observe the efficacy of PEG-interferon in the patients with chronic hepatitis B and the gerum ferritin level.Results There is a light plus correlation between The increased serum ferritin level and serve grade of liver disease.Among 50 cases treated by PEG-interferon The effect in the group of serum ferritin400ng/ml is better than in the group of serum ferritin 400ng/ml and over（P0.05）.It is suggested that the serum ferritin level inereased,the Response rate to PEG-interferon declined.It is statistically singnificant between substained and transient response Group in 25 cases responses（P0.05）.Concluaion It is suggested that serum ferritin level is an Important factor of influence to in the treatment of chronic hepatitis B by PEG-interferon.

关 键 词：慢性乙型肝炎 聚乙二醇干扰素 血清铁蛋白 

分 类 号：R512.6[医药卫生—内科学]