急诊介入联合替罗非班在急性心梗患者中应用的安全性与近期预后评价  

Safety and recent outcomes of emergency interventional procedures combined with tirofiban in patients with acute myocardial infarction

作　　者：白红颖[1] 丁宁[1] 

机构地区：[1]首都医科大学附属北京同仁医院,北京100005

出　　处：《海南医学院学报》2011年第4期484-487,共4页Journal of Hainan Medical University

基　　金：海南医学院科研基金资助学报项目(0020110107)~~

摘　　要：目的：观察替罗非班在急性心肌梗死患者急诊介入治疗中的疗效、安全性及近期预后。方法：选取2007年1月2010年1月于发病12 h内在我院接受急诊介入治疗的急性心肌梗死患者66例,随机分为观察组和对照组,全部患者均给予阿司匹林、氯吡格雷及肝素,观察组额外使用替罗非班。观察两组患者住院期间出血事件、心电图、左室射血分数、主要不良心脏事件发生情况,并作出统计分析。结果：观察组和对照组血小板减少症的发生率为（3.1%vs 2.9%）,轻度出血和重度出血发生率分别为（9.4%vs 11.8%,3.1%vs 2.9%）,差异无统计学意义（P〉0.05）。观察组在术后2 h的平均sumSTR略高于对照组（45.9±27.1）vs（45.1±25.8）,差异无统计学意义（P〉0.05）。观察组在术后30 d和3个月的LVEF均高于对照组（53.0±6.2）vs（46.5±5.9）,（57.0±5.8）vs（50.8±4.7）,差异有统计学意义（P〈0.05）。观察组和对照组在术后30 d及3个月的MACE发生率为（3.1%vs 14.7%,9.3%vs 26.5%）,差异有统计学意义（P〈0.05）。结论：急诊介入联合使用替罗非班治疗急性心肌梗死,不增加出血事件、安全性良好,患者的近期预后良好。Objective： To observe and assess the curative effect,safety and recent outcomes of emergency interventional procedures combined with tirofiban in patients with acute myocardial infarction.Methods： A total of 66 patients with acute myocardial infarction that underwent interventional procedures within 12 h after onset from January 2007 to January 2010 were assigned into observation and control group,respectively.Both groups were given aspirin,clopidogrel and heparin,while the observation group was also given an extra tirofiban.Clinical outcomes during hospitalization,ECG,LVEF and MACE was observed and compared between the two groups.Results： Prevalence of thrombocytopenia,mild and severe hemorrhage in the observation group and control group was 3.1% vs 2.9%,9.4% vs 11.8% and 3.1% vs 2.9%,showing no significant difference（P〉0.05）.The average sum STR 2 hours after operation of the observation group was a little higher than that of the control group（45.9±27.1 vs 45.1±25.8）（P〉0.05）.The observation group showed higher LVEF 30 days or 3 months after the operation,（53.0±6.2 vs 46.5±5.9,57.0±5.8 vs50.8±4.7）showing significant difference（P〈0.05）.The MACE incidence 30 days and 3 months after operation in the observation group and control group were 3.1% vs 14.7%,9.3% vs 26.5%,the difference were statistically significant（P〈0.05）.Conclusions： With favorable outcomes,emergency interventional procedures combined with tirofiban is effective and safe in patients with acute myocardial infarction

关 键 词：替罗非班 急性心肌梗死 安全性 预后 

分 类 号：R54[医药卫生—心血管疾病]