肠杆菌科细菌对头孢曲松耐药趋势的国内文献分析  

Drug resistant trend of enterobacteriaceae to ceftriaxone based on domestic literatures

作　　者：陈昭丽[1,2] 张兴艳[1,2] 李苌青 王广基[3] 王霆[1,2] 

机构地区：[1]中南大学,湖南长沙410013 [2]湘北威尔曼制药有限公司及制药研究所,湖南长沙410000 [3]中国药科大学,江苏南京210009

出　　处：《中华医院感染学杂志》2011年第9期1873-1876,共4页Chinese Journal of Nosocomiology

摘　　要：目的了解我国2000年以来各地区肠杆菌科细菌对头孢曲松的耐药趋势。方法检索中国期刊全文数据库,筛选质量合格文献,文献中的数据按不同地区、不同年份、不同种类肠杆菌科细菌菌株进行归类、计算和分析。结果共筛选文献68篇,经分析,不同年份、不同地区以及不同种类肠杆菌科细菌对头孢曲松的耐药率存在差异;大肠埃希菌、肺炎克雷伯菌耐药率呈上升趋势,2000-2008年分别增长了18.4%、18.8%,肠杆菌科细菌耐药率与产ESBLs检出率增加密切相关,而非产ESBLs菌对头孢曲松的耐药率保持在较低水平,但2005年来有增长趋势。结论 2000-2008年我国临床分离肠杆菌科细菌对头孢曲松的耐药率呈上升趋势,其耐药率的增长可能主要由产ESBLs菌的流行所致,其次同非产ESBLs菌耐药率升高有关。OBJECTIVE To investigate the situation and tendency of ceftriaxone resistance to clinical isolates of Enterobacteriaceae.METHODS The references related to ceftriaxone resistance were gathered by the CNKI datebase.The resistance rates of different strains of bacteria were assayed in various regions and years.RESULTS The results showed that the resistant rates of each strains of Escherichia coli,and Klebsiella pneumoniahad been increasing by 18.4% and 18.8% in last nine years basing on 68 scientific references eventually chosen.There was a positive correlation between the resistance rates to cefriaxone and detection rate of ESBLs-producing Enterobacteriaceae,meanwhile the resistance rate of non-ESBLs producing Enterobacteriaceaeto ceftriaxone remains in lower lever,but with its significant growing trends yearly since 2005.CONCLUSION The resistant rates to ceftriaxone of clinical Enterobacteriaceaedisplay an upward tendency from 2000 to 2008.The resistance of Enterobacteriaceaeto the antibiotics may be mainly due to its production of ESBLs,and the secondary causes may be the increasing resistance rate of non-ESBLs-producing Enterobacteriaceae.

关 键 词：头孢曲松 耐药率 肠杆菌科细菌 超广谱Β-内酰胺酶 

分 类 号：R978.1[医药卫生—药品]