鲍氏不动杆菌感染的临床分布及耐药性分析  

Clinical distribution of infection caused by aicinetobacter baumannii and its drug resistance

作　　者：诸林俏[1] 黄晨[1] 

机构地区：[1]温州医学院附属第二医院药剂科,浙江温州325027

出　　处：《中华医院感染学杂志》2011年第9期1900-1902,共3页Chinese Journal of Nosocomiology

摘　　要：目的了解医院鲍氏不动杆菌感染的分布及药敏情况,为临床治疗提供依据。方法对医院2008年1月-2009年12月临床分离鲍氏不动杆菌标本来源、分布科室及药敏试验结果进行回顾性分析。结果共检出196株鲍氏不动杆菌,分离率居前3位的临床科室依次为ICU、神经内科、呼吸内科,分别占24.5%、18.4%、15.3%;痰标本鲍氏不动杆菌的检出率最高,达78.1%;对14种常用抗菌药物的耐药率除头孢哌酮/舒巴坦、亚胺培南、美罗培南和阿米卡星较低外,其余抗菌药物耐药率均>50.0%。结论鲍氏不动杆菌对头孢哌酮/舒巴坦、亚胺培南、美罗培南、阿米卡星较敏感,对其他抗菌药物耐药情况严重,临床上应根据其临床分布特点和药敏试验结果选用合理抗菌药物。OBJECTIVE To investigate the distribution and drug resistance of clinical Acinetobacter baumannii,and offer reasonable experimental data for the clinical therapy.METHODS The clinical isolates of the specimen source of A.baumannii,the distribution of technical offices and the result of drug sensitivity test from Jan 2008 to Dec 2009 in hospital were retrospectively analyzed.RESULTS A total of 196 cases of A.baumanniiwere isolated.The top three of isolated rates were the intensive care unit（24.5%）,department of neurology（18.4%） and department of respiratory medicine（15.3%）.The highest appearing rate was from the sputum,up to 78.1%.More than 50.0% of isolates were resistant to all antimicrobial agents tested except cefoperazone/sulbactam,imipenem,meropenem and amikacin.CONCLUSION Most of A.baumanniiisolates are susceptible to cefoperazone/sulbactam,imipenem,meropenem and amikacin and resistant to other antimicrobial agents,It is necessary to choose the antibiotics sensitive to A.baumanniiaccording to the clinical distribution and the result of drug sensitive test.

关 键 词：鲍氏不动杆菌 抗菌药物 耐药性 

分 类 号：R378[医药卫生—病原生物学]