304株胆道感染病原菌及其药敏分析  

Study on 304 strains of pathogenic bacteria causing biliary tract infection and their sensitivity to antibiotics

作　　者：袁兴贵[1] 严培军[1] 俞南松[1] 朱小祥[1] 崔昱春[1] 鲁葆春[1] 

机构地区：[1]绍兴市人民医院肝胆外科,浙江绍兴312000

出　　处：《中华医院感染学杂志》2011年第9期1912-1914,共3页Chinese Journal of Nosocomiology

摘　　要：目的了解胆道感染时胆汁中致病菌菌群及耐药变化趋势。方法将2006年1月-2009年12月培养阳性的269例胆汁标本,共304株病原菌及药敏结果进行统计分析。结果 304株细菌中包含了52种细菌,其中革兰阴性杆菌占59.5%,革兰阳性球菌占40.5%,排列前5位的细菌依次为:大肠埃希菌20.4%、粪肠球菌16.8%、肺炎克雷伯菌11.2%、铜绿假单胞菌8.9%、阴沟肠杆菌7.9%;细菌对青霉素类、头孢类、喹诺酮类、大环内酯类抗菌药物敏感性普遍下降,对亚胺培南、美罗培南、万古霉素、替考拉宁仍保持相当高的敏感率。结论胆道感染菌种在增加,菌群在变化,对常用的抗菌药物耐药率在增加;治疗胆道感染应动态监测菌群和药物敏感性的变化及合理应用抗菌药物。OBJECTIVE To study the changing tendency of drug resistance of pathogenic bacteria in bile causing biliary tract infection.METHODS The data of 304 strains of aerobes isolated from 269 patients with positive bile culture from Jan 2006 to Dec 2009 and their sensitivity to antibiotics were analyzed.RESULTS The 304 strains of aerobes belonged to 52 species：Gram-negative bacteria accounted for 59.5% and Gram-positive coci accounted for 40.5%.The leading five bacteria detected were Escherichia coli（20.4%）,Enterococcus faecalis（16.8%）,Klebsiella pneumoniae（11.2%）,Pseudomonas aeruginosa（8.9%） and Enterobacter cloacae（7.9%）.The sensitivities of the bacteria to penicillin,cephalosporins and quinolones were generally declined.However,they were highly sensitive to imipenem,meropenem,vancomycin and teicoplanin.CONCLUSIONS Types of pathogens of biliary tract infection and their antibiotic resistance are increasing.So it is important to keep on detecting the changes of antibiotics sensitivity and rationally using the antibiotics.

关 键 词：胆道感染 致病菌 药敏试验 

分 类 号：R378[医药卫生—病原生物学]