5′-脱氧-5′-乙酰硫代核苷的一步法合成  

One-step synthesis of 5′-acetylthio-5′-deoxynucleoside

作　　者：胡守印[1] 林东恩[1] 张逸伟[1] 

机构地区：[1]华南理工大学化学与化工学院,广东广州510640

出　　处：《化学试剂》2011年第5期460-462,共3页Chemical Reagents

摘　　要：一种合成标题化合物的新方法。分别以腺苷、肌苷、尿苷、利巴韦林和硫代乙酸为原料,通过Mitsunobu反应一步法合成了4种标题化合物,收率分别为68.4%、69.8%、73.4%、65.0%,并根据该反应对核苷5-′OH具有较高选择性这一结果提出了该反应可能的机理,所有产物结构均通过1HNMR、ESI-MS确证。A convenient method for synthesizing a series of 5′-acetylthio-5′-deoxynucleoside was reported,with which four 5′-acetylthio-5′-deoxynucleoside were obtained in a yield of 68.4%,69.8%,73.4%,65.0% respectively using adenosine,inosine,uridine,ribavirin and thioacetic acid through mitsunobu reaction in one step.The possible mechanism of this method was provided based on the fact that 5′-OH can be selectively replaced by acetylthio groups in the presence of 2′,3′-OH.The structure of all target compounds were confirmed by 1HNMR and ESI-MS.

关 键 词：腺苷 肌苷 利巴韦林 尿苷 核苷 

分 类 号：O626.1[理学—有机化学]