降钙素基因相关肽受体组分蛋白  

Researches of calcitonin gene-related peptide receptor component protein

作　　者：唐江琼[1] 秦旭平[1] 

机构地区：[1]南华大学药物药理研究所,衡阳421001

出　　处：《生命的化学》2011年第2期277-280,共4页Chemistry of Life

基　　金：国家自然科学基金(30572192);湖南省自然科学基金(05JJ30042);南华大学学术带头人培养对象资金资助

摘　　要：降钙素基因相关肽受体组分蛋白(calcitonin gene-related peptide-receptor component protein,CGRP-RCP)是降钙素基因相关肽受体的一个具有146/148个氨基酸的胞内膜周边蛋白,特异地与降钙素受体样受体(calcitonin receptor-like receptor,CRLR)相互作用并促进CGRP和肾上腺髓质素的信号跨膜转导,现认为CGRP-RCP也是G蛋白偶联受体中一个动态的调节器。CGRP-RCP的mRNA在人和鼠的几乎所有组织均可检测到,在小鼠睾丸中分布尤其明显。在哺乳动物中,CGRP-RCP与C17(酵母菌中聚合酶III的必需亚基)是直系同源蛋白,人体的CGRP-RCP能取代酵母中的C17,发挥与C17相同的生物学作用。Calcitonin gene-related peptide receptor component protein（CGRP-RCP）,an additional accessory protein of the calcitonin gene-related peptide receptor and an intracellular peripheral membrane protein,is composed of 146–148 residues,which interacts specifically with the calcitonin receptor-like receptor（CRLR） and facilitates signal transduction by CGRP and adrenomedullin.Furthermore,CGRP-RCP is a dynamic regulator of G protein-coupled signal transduction,and implies an additional level of receptor regulation unique to the CGRP system.The CGRP-RCP mRNA is expressed in all tissues of the human and mice,especially more in the testis of mice.Moreover,CGRP-RCP is the mammalian orthologue of C17（an essential subunit of yeast RNA polymerase） and human RCP could functionally replace its orthologue in yeast.

关 键 词：降钙素基因相关肽受体 降钙素基因相关肽受体组分蛋白 降钙素受体样受体 受体活性修饰蛋白-1 

分 类 号：R341[医药卫生—基础医学]