大黄酚脂质体的制备工艺研究  

Preparation and quality evaluation of chrysophanol liposome

作　　者：王永利[1] 张明媚[2] 李维爽[3] 张丹参[4] 

机构地区：[1]河北北方学院应用化学研究所,张家口075000 [2]北京工业大学环境与能源工程学院,北京100124 [3]天津科技大学材料科学与化学工程学院,天津300457 [4]河北北方学院基础医学院,张家口075000

出　　处：《中国新药杂志》2011年第9期825-827,832,共4页Chinese Journal of New Drugs

基　　金：张家口市科学技术研究与发展计划项目(0921100D)

摘　　要：目的:对大黄酚脂质体的处方和制备工艺进行研究,并评价其质量。方法:采用薄膜-超声分散法制备了大黄酚脂质体,并对制剂的包封率、形态学、粒径分布、稳定性等进行研究。结果:本研究制备的大黄酚脂质体处方为药脂比3∶30,脂材比1∶3,成膜温度为45℃,缓冲溶液pH为8.2,得到的脂质体粒径均匀,包封率达86.9%。结论:采用薄膜-超声分散法制备的大黄酚脂质体具有较高包封率和稳定性。Objective：To prepare and evaluate the quality of chrysophanol liposome.Methods：The liposome was prepared by film-ultrasonic wave technology.The morphology,entrapment,size distribution and stability of chrysophanol liposome were studied.Results：The optimal formulation was drug/PC=3∶30,CHOL/PC=1∶3,at 45 ℃ reactive temperature,and pH=8.2 in buffer solution.The size of obtained liposome was uniform and entrapment efficiency reached 86.9%.Conclusion：Prepared by the film-ultrasonic wave technology,chrysophanol is highly entrapped into liposome with good stability.

关 键 词：大黄酚 脂质体 薄膜-超声分散法 低速离心法 包封率 

分 类 号：R943.4[医药卫生—药剂学]