烧伤对垂体—睾丸轴影响的临床研究  

Clinical studies on the effects of burn trauma on pituitary-testis axis

作　　者：马克娴[1] 段体武[1] 达明绪[1] 

机构地区：[1]昆明医学院第二附属医院烧伤研究室,昆明650101

出　　处：《中华整形烧伤外科杂志》1999年第5期373-375,共3页

摘　　要：目的探讨烧伤对垂体—睾丸轴功能的影响。方法采用 RIA 法测定了28例男性烧伤患者伤后30天内血清卵泡生成素(FSH)、黄体生成素(LH)、睾酮(T)及雌二醇(E_2)水平的动态变化。结果烧伤后血清 FSH、LH、T 水平明显降低,伤后2周左右开始有所回升,而 BSA>30％TBSA 两组患者,伤后30天仍未完全恢复正常水平;E_2水平伤后明显增高,尔后逐步下降至正常水平;死亡组平均 T 水平显著低于存活组,平均 E_2水平显著高于存活组。结论烧伤后垂体功能本身可能受抑制,E_2、T 之间的失衡有可能参与烧伤免疫抑制过程,E_2、T 水平变化幅度随烧伤严重程度增加而加剧,是反映烧伤程度较为敏感的指标。Objective To investigate the effects of burn trauma on pituitary-testis axis.Methods The changes in serum estradiol (E_2),testosterone (T),luteinizing hormone (LH),and follicle stimulating hormone(FSH) levels were dynamically investigated by RIA in 30 days after thermal injury in 28 burnt men.Results The serum FSH,LH,and T levels significantly decreased after injury,and there was some increase from PBD(postburn day) 14 to 30.In patients in group Ⅱ and Ⅲ (BSA>30% TBSA),not all of their FSH,LH,and T levels reached the normal control on the PBD 30.Serum E_2 levels were elevated af- ter injury,then returned gradually to normal.In three patients who died,their mean T levels were signifi- cantly lower than patients who survived,but mean E_2 levels were significantly higher than that of sur- vivors.Conclusion The activity of pituitary might be depressed after burn trauma.The imbalance be- tween E_2 and T might play a role in the processes of immuno-depression after injury.The changed extent of E_2 and T levels was correlated to burn size.They could be sensitive indicators of burn stress.

关 键 词：烧伤 卵泡刺激素 黄体生成素 睾酮 雌二醇 

分 类 号：R644[医药卫生—外科学] R977.1[医药卫生—临床医学]