光引发氯霉素分子印迹聚合膜的原位合成及性能测试  

In Situ Synthesis and PerformanceTesting of Chloramphenicol Molecular Imprinted Polymer Membrane Induced by Light

作　　者：张贤珍[1] 余盛禄[1] 孙德四[1] 

机构地区：[1]九江学院化学化工学院,江西九江332005

出　　处：《安徽农业科学》2011年第12期7253-7254,7290,共3页Journal of Anhui Agricultural Sciences

基　　金：九江学院科技项目(06KJ5)

摘　　要：[目的]寻求检测氯霉素的简单方法。[方法]用紫外光引发,在压电传感器电极上原位合成氯霉素分子印迹聚合膜。分析功能单体的种类、用量对聚合膜的影响,考察传感器对氯霉素的作用。[结果]在氯霉素作模板分子、甲基丙烯酸二乙氨基酯作功能单体、氯霉素与甲基丙烯酸二乙氨基酯用量1∶2时,分子印迹聚合膜的响应最佳。在30～160μg/L时传感器对氯霉素的响应呈线性关系,检测下限为30μg/L。[结论]氯霉素分子印迹聚合膜可以用作压电传感器的识别元件。[Objective] The aim of the study was to seek the simple method of chloramphenicol measurement.[Method] At the electrode of piezoelectric sensor,in situ synthesis of chloramphenicol（CAP） molecular imprinted polymer membrane was reduced by UV irradiation.It was studied that the response of the polymer film to the species and amount of functional monomer.The interacion between the sensor and chloramphenicol was investigated.[Result] Using chloramphenicol as template molecule,methacrylic acid 2-Diethylaminothyl ester（DAM） as functional molecule,,the molecular imprinted polymer film had higher affinity for chloramphenicol when CAP∶DAM was1∶2.The frequency shift of the sensor was proportional to the concentration of chloramphenicol over the range of 30-160 μg/L.The detection limit was 30 μg/L.[Conclusion]chloramphenicol molecular imprinted polymer film could be used as recognition element of piezoelectric sensors.

关 键 词：氯霉素 分子印迹 原位 压电传感器 

分 类 号：R978.1[医药卫生—药品]