氨氯地平治疗肾性高血压的疗效和安全性  

Efficacy and safety of amlodipine on renal hypertension

作　　者：丁小强[1] 吴兆龙[1] 葛煜强[1] 陶凤武[1] 廖履坦[1] 

机构地区：[1]上海医科大学附属中山医院肾内科,上海200032

出　　处：《中国新药与临床杂志》1999年第5期262-265,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :观察氨氯地平治疗肾性高血压的疗效和安全性。方法 :前瞻性研究。肾性高血压病人 96例 ,分 2组 ,氨氯地平单用组 5 4例 [男性 30例 ,女性2 4例 ;年龄 ( 38±s 19)a]给氨氯地平 10mg ,po ,qm ( 7∶0 0 )× 6wk(如治疗 2wk未达显效可剂量加倍 ) ;氨氯地平与依那普利合用组 42例 [男性 2 6例 ,女性 16例 ;年龄 ( 41± 2 0 )a]在原用依那普利 10mg ,po ,qd或bid基础上加用氨氯地平 (用法同上 )× 6wk。结果 :单用组总有效率 80 % ,合用组为98% (P <0 .0 1) (其中对重度高血压的有效率分别为 42 %和 80 % ,P >0 .0 5 ) ,不良反应均较少而轻。结论 :单用或合用氨氯地平治疗轻、中度肾性高血压疗效均较好 ,对重度高血压以加用依那普利的合用组似较好。AIM: To evaluate the efficacy and safety of amlodipine on renal hypertension. METHODS: Renal hypertensive 96 patients were divided into amlodipine group [n=54, M 30, F 24; age (38±s 19) a] were given 10 mg, po, qm×6 wk; and combined group [n=42, M 26, F 16; age (41±20) a] were given enalapril 10_20 mg, po, qm×6 wk, and with amlodipine was the same as described above. RESULTS: The total effective rate were 80% and 98% with only (42% and 80% for severe hypertension) in amlodipine group and combined group, respectively(P<0.01). CONCLUSION: Amlodipine is effective and safe for the treament of mild or moderate renal hypertension, it is necessary to combine with enalapril to treat severe ranal hypertension.

关 键 词：氨氯地平 肾性高血压 治疗 安全性 

分 类 号：R544.140.5[医药卫生—心血管疾病]