地尔硫静脉滴注治疗充血性心力衰竭  

Diltiazem with intravenous drip in treating congestive heart failure

作　　者：汪向明[1] 张凤如[2] 潘秀芳[2] 胡厚达[2] 葛孝虹[2] 施仲伟[2] 王书成[2] 

机构地区：[1]上海市东南医院,上海200023 [2]上海第二医科大学附属瑞金医院心内科,上海200025

出　　处：《中国新药与临床杂志》1999年第5期293-295,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :观察地尔硫静脉滴注治疗充血性心力衰竭 (CHF)的疗效。方法 :轻、中度CHF住院病人 2 8例 (男性 16例 ,女性 12例 ;年龄 64a±s 11a) ,以地尔硫注射液 30～ 5 0mg加于 5 %葡萄糖注射液 2 5 0mL或 0 .9%氯化钠注射液 2 5 0mL中静脉滴注 ,qd ,共 10d。结果 :治疗 10d后每搏输出量(SV)升高 ( 10± 11)mL/搏 ,左室射血分数 (LVEF)升高 ( 10± 10 ) % ,差别均有非常显著意义 (P <0 .0 1) ;心率减慢差值为 ( 9± 6)次 /min与血压下降SBP ( 2± 4)kPa ,DBP ( 2± 3)kPa ,差别均有显著或非常显著意义 (P <0 .0 5或P <0 .0 1) ;临床总有效率 71% ,未发现严重的不良反应。结论 :地尔硫静脉滴注治疗轻。AIM: To observe the clinical efficacy of diltiazem with intravenous drip in treating congestive heart failure (CHF). METHODS: Twenty_eight hospitalized patients [M 16, F 12; age (64±s 11) a] with mild to moderate CHF were treated with diltiazem 30_50 mg in 5 % glucose injection 250 mL or 0.9 % sodium chloride injection 250 mL, iv, drip, qd for 10 d. RESULTS: Intravenous drip of diltiazem improved left ventricular systolic function, increased cardiac output, for example, stroke volume was elevated (10±11) mL/beat and left ventricular ejection fraction was elevated (10±10) % (P<0.01), decreased heart rate (9±6)beat/min and blood pressures [SBP(2±4)kPa, DBP(2±3)kPa] (P<0.05 or P<0.01 ). The total clinical efficacy rate was 71%, and no serious adverse reactions were found. CONCLUSION: It is safe and effective to treat mild to moderate CHF with intravenous drip of diltiazem for a brief periods.

关 键 词：地尔硫Zhou 充血性 心力衰竭 治疗 

分 类 号：R541.605[医药卫生—心血管疾病]