血管紧张素转换酶基因多态性与血管紧张素转换酶抑制剂的降压作用  

ANGIOTENSIN CONVERTING ENZYME GENE POLYMORPHISM IN UNTREATED ESSENTIAL HYPERTENSION AND RESPONSE TO ANGIOTENSIN CONVERTING ENZYME INHIBITORS

作　　者：曹文[1] 凌树森[2] 张启高[2] 陈亚利[2] 

机构地区：[1]南京军区南京总医院临床药理科,南京210002 [2]南京军区南京总医院,南京210002

出　　处：《药学学报》1999年第9期655-657,共3页Acta Pharmaceutica Sinica

摘　　要：目的：从基因多态性研究药效的差异。方法：选择健康志愿者９９ 例，未治疗的原发性高血压病人４０ 例，用 Ｐ Ｃ Ｒ 方法检测血管紧张素转换酶（ Ａ Ｃ Ｅ） 基因的插入与缺失（ Ｉ／ Ｄ） 多态性， 用血管紧张素转换酶抑制剂（ Ａ Ｃ Ｅ Ｉ） 卡托普利治疗高血压病人。结果：正常人与原发性高血压患者的 Ａ Ｃ Ｅ 等位基因频率及基因型频率无显著差异（ Ｐ＞００５） 。卡托普利降压有效病人与无效病人 Ａ Ｃ Ｅ 基因的 Ｉ／ Ｄ 等位基因频率及基因型频率，基因缺失型纯合子（ Ｄ Ｄ）或／ 和杂合子（ Ｉ Ｄ） 与非缺失型（ Ｉ Ｉ） 也均无显著差异（ Ｐ＞ ００５） 。结论： Ａ Ｃ Ｅ 基因的 Ｉ／ Ｄ 多态性与原发性高血压的发病无关， Ａ Ｃ Ｅ Ｉ降压作用的个体差异与 Ａ Ｃ Ｅ 基因的 Ｉ／ Ｄ 多态性无关。AIM: To study the insertion/deletion(I/D) polymorphism of angiotensin converting enzyme (ACE) gene in untreated essential hypertension, and the effect of angiotensin converting enzyme inhibitor(ACEI) on the gene polymorphism. METHODS: I/D Polymorphism in intron 16 of the ACE gene were determined by polymerase chain reaction (PCR) in 99 normotensive subjects and 40 patients with untreated essential hypertension before and after captopril treatment (50 mg twice daily). The change of diastolic blood pressure achieved was analyzed for association with genotypes at the ACE gene. RESULTS: No significant difference was found on the alleles frequencies and on the genotype frequencies between normotensive and hypertensive groups, effective and no effective response to ACEI groups( P >0 05). Statistical analysis of DD genotype and non DD genotype, non II genotype and II genotype showed no significant difference between normotensive and hypertensive groups, effective and noneffctive response to ACEI groups( P >0 05). CONCLUSION: Deletion polymorphism of the ACE gene is not associated with essential hypertension. The variability between individuals in the observed blood pressure response to ACEI cannot be attributed to the polymorphisms analyzed at the ACE gene.

关 键 词：ACE 基因多态性 高血压 ACEI 降压作用 

分 类 号：R972.4[医药卫生—药品]