慢性阻塞性肺疾病患者血液流变学指标及ET、SOD水平变化的临床观察  

Clinical Study on Changes of Hemorheology,Endothelin and Superoxide Dismutase in Patients with Chromic Obstructive Pulmonary Disease

作　　者：陈章[1] 白小红[1] 王利[2] 关静[1] 

机构地区：[1]成都军区总医院呼吸内科,邮政编码成都610083 [2]四川乐山市人民医院

出　　处：《微循环学杂志》2011年第2期30-31,I0001,共3页Chinese Journal of Microcirculation

摘　　要：目的:观察慢性阻塞性肺疾病(COPD)患者血液流变学指标及血浆内皮素(ET)和血清超氧化物歧化酶(SOD)水平的变化。方法:采用自动血流变测试仪测定COPD患者血液流变学指标,用RIA法测定血浆ET和血清SOD水平,并与健康对照组比较。结果:COPD患者血液流变学指标有明显变化,低切变率和高切变率全血粘度以及血浆粘度均增高,与对照组比较差异显著(P<0.05),血浆ET浓度明显高于对照组(P<0.01),而血清SOD含量明显低于对照组(P<0.05)。结论:COPD患者血液流变学指标异常、微循环障碍以及ET和SOD血液水平的变化是其病理改变的重要环节。Objective:To study the changes of hemorheology,endothelin(ET) and superoxide dismutase(SOD)in patients with chronic obstructive pulmonary disease(COPD).Method:Hemorheoloical index in 62 patients with COPD and 60 person in control group were examined by SA-6000 type auto-hemorheological examin instrument.Serum ET and SOD was measured by RIA.Results:Differential change of hemorheology index in the patients with COPD had occurred.Blood viscosity and serum viscosity were increased.Hemorheoloical index of COPD group compared with control group was siginificant defference(P<0.05).ET was higher than control group(P<0.01)and SOD was lower than control group(P<0.05).Conclusion:Hemorheoloical index has marked change in the patients with COPD.The microcirculation distubance,changes of ET and SOD play an important role in pathophysiology of COPD.

关 键 词：慢性阻塞性肺疾病 血液流变学 内皮素 超氧化物歧化酶 

分 类 号：R563.4[医药卫生—呼吸系统]