铅对小鼠睾丸组织脂质过氧化作用及杭白菊对其保护作用的研究  

A STUDY ON EFFECT OF LEAD AND PROTECTIVE EFFECT OF CHRYSANTHEMUM ON LIPID PEROXIDATION IN TESTICLE TISSUE OF MICE

作　　者：范广勤[1] 朱建华[1] 冯昶[1] 刘延芳[1] 李伟[1] 

机构地区：[1]江西医学院预防医学系,330006

出　　处：《现代预防医学》1999年第3期308-309,共2页Modern Preventive Medicine

摘　　要：本文通过给雄性小鼠腹腔注射醋酸铅染毒，测定各不同染毒剂量组与空白对照及杭白菊灌胃组中血铅、血浆中VitC和小鼠睾丸组织中T—SOD、GSH—Px活力，MDA含量．以观察铅对小鼠睾丸组织脂质过氧化作用及杭白菊对其保护作用。结果表明：铅染毒组T—SOD活力和GSH—Px活力下降．其中T—SOD活力与铅含量呈负相关（r＝-0．6098，P＜0．01）；杭白菊灌胃组T—SOD和GSH—Px活力上升，与铅染毒组相比，差异显著（P＜0．05），其中GSH—Px恢复到对照水平。杭白菊灌胃组较染毒组血铅含量下降，血浆中VitC含量上升，差异显著（P＜0．05）。Lipid peroxidation in testicle tissue and the protective effect of chrysanthemum were studied, when mice were injured lead eceloxy by abdominal and poured chysanthemum tea by stomach. The results showed that the superoxide dimutase (SOD) and the glutathione peIOxidase (GSH-Px) activity decreased in lead exposed group, there was negative correlation between SOD activity and lead in blood (r=-0. 6089, P<0.01). In chysanthemum group, SOD and GSH-Px activity increased significantly. There was significant difference in lead and Vit C in blood between lead exposed group and chrysanthemum group. In chrysanthemum group, lead in blood decreased, Vit C in blood increased.

关 键 词：铅 杭白菊 脂质过氧化 睾丸组织 

分 类 号：R995[医药卫生—毒理学] R992[医药卫生—药学]