HBV不同血清学标志组合中HBV-DNA的分布特征  

DISTRIBUTIVE CHARACTERISTIC OF HBV-DNA IN DIFFERENT COMBINATIONS OF SEROLOGICAL MARKERS FOR HBV

作　　者：张留寿 吴淑华[1] 钱霞[1] 徐强 唐晓丽[1] 

机构地区：[1]江苏省泰兴市卫生防疫站,225400

出　　处：《现代预防医学》1999年第3期396-397,共2页Modern Preventive Medicine

摘　　要：采用聚合酶链反应（PCR）技术对270例HBV不同血清学标志及不同组合进行了HBV-DNA的检测。揭示HBV-DNA在HBeAg标志中检出率最高，阳性率为100．00％；其次是HBsAg、抗-HBc和抗一HBe，阳性率分别为66．0％、65．9％和46．2％；在抗-HBS标志物中未能检出HBV-DNA。并示出了HBV-DNA在HBV血清学标志不同组合中的阳性率有着非常显著性差别，研究表明，在HBeAg阴性组合中，采用聚合酶链反应技术检测HBV-DNA的临床意义，同明还分析了HBV-DNA与性别、HBsAg滴度及ALT的关系。A study on the detection of HBV-DNA was conducted by Polymerase Chain Realtion (PCR) among 270 cases of different combination. The result showed of the detective rate of HBV-DNA was the highest in HBe marker with it's 100% positive rate, and consequently in HBsAg Anti-HBC and Anti-HBe with their positive rate being 66%, 65. 9% and 46. 2% respeqively, but HBV-DNA hadn't been detected in anti-HBs marker. And the result showed that there's a significant difference amog thepositive rate of HBV-DNA in different combinations of Serological markers for HBV. This study demonstrated the clinical significance of detecting HBV-DNA by PCR in the combination of negative HBeAg, meanwhile we analyzed the relationship betweem HBV-DNA and sex. HBsAg titer. ALT.

关 键 词：聚合酶链反应 HBV-DNA 乙肝血清学标志 

分 类 号：R512.601[医药卫生—内科学]