益母草联合缩宫素预防剖宫产术后出血促子宫复原的临床研究  

Motherwort combined with oxytocin in the prevention of postpartum hemorrhage and the acceleration of uterine restoration

作　　者：付玉芬[1] 

机构地区：[1]淄博市妇幼保健院产科,255029

出　　处：《国际医药卫生导报》2011年第9期1103-1105,共3页International Medicine and Health Guidance News

摘　　要：目的探讨预防刮宫产术后卅血及促子宫复原的有效方法。方法选取可能发生产后出血的高危剖宫产患者126例，随机分为观察组和对照组各63例。治疗组给予益母草联合缩宫素治疗，对照组只给予缩宫素治疗。对比观察两组术中、术后阴道流血量及术后5天平均每日宫底下降高度，了解子宫复原情况。结果治疗组术中、术后2h、12h、24h、48h阴道出血量均少于对照组，差异有统计学意义（P〈0．05）。术后5天观察组测量的平均每日宫底下降的高度均高于对照组，差异有统计学意义（P〈0．05）。治疗组子宫底下降速度快（P〈0．05）。结论缩宫素起效快，半衰期短，益母草半衰期长，缩宫效果持续而缓慢，两者联合应用于预防剖宫产术后出血具有互补协同作用，能加强子宫收缩，促子宫复原，预防产后出血，安全性好。Objective To explore the effective methods for the prevention of postpartum hemorrhage and the acceleration of uterine restoration. Methods 126 women at high-risks of postpartum hemorrhage after Cesarean section were randomly assigned to receive motherwort combined with oxytoein （ 63 women, study group ）or oxytocin alone （ 63 women, control group ）. The intraoperative and postoperative vaginal bleeding volumes were compared between the two groups, so was the average decreased height of the fundus to determine uterine restoration, Results The bleeding volumes were significantly less in the study group than in the control group intraoperatively, and at hours 2, 12, 24, and 48 （ P〈 0.05 ）. 5 days after treatment, the daily decreased height of fundus was greater in the study group than in the control group （ P〈 0.05 ）. The speed of the decrease in fundus was quicker in the study group （ P 〈 0.05 ）. Conclusions Oxytocin has a rapid onset of action and a shorter half-life while motherwort has a longer half-life and a slow action. The combination therapy has a synergistic action. It can strengthen uterine contraction, accelerate uterine restoration, and revent postpartum hemorrhage, and is safe.

关 键 词：剖宫产术 产后出血 益母草注射液 缩宫素 子宫复原 

分 类 号：R7[医药卫生—临床医学]