DNA芯片技术与新药的设计和开发  

DNA Chip Technology in New Drug Design and Development

作　　者：孙凌[1] 张建中[1] 

机构地区：[1]解放军306医院,北京市100101

出　　处：《中国药房》1999年第5期196-197,共2页China Pharmacy

摘　　要：目的：介绍DNA芯片技术和评价其在新药设计和开发中的价值；方法：查阅和综述近年来有关文献。结果：DNA芯片技术可同时检测和分析几千种基因的表达类型，为基因的功能研究和新药开发提供线索。结论：DNA芯片有助于识别药物相应靶序列，亦可用于监视药物治疗反应的基因表达改变.OBJECTIVE: To brief pharmacologists on DNA chip technology and evaluate its role in new drug design and development. METHODS: To review the relevant articles Published in recent years. RESULTS: DNA chips could be used tomeasure the expression patterns of thousands of genes simultaneously, generating clues to gene function and new drug design.CONCLUSION: DNA chip technology can help to identify appropriate target sequence for therapeutic intervention, and can alsobe used to monitor changes in gene expressions in response to drug treatment.

关 键 词：DNA芯片 药物开发 基因表达 靶序列 设计 

分 类 号：R915[医药卫生—微生物与生化药学]