快速搅拌制备肠必清微丸的工艺研究  

Study of Preparation Technology of Chang Bi Qing Pellets by High Speed Mixer

作　　者：刘圣[1] 陈象清[1] 田莉[1] 陈礼明[1] 胡世莲[1] 

机构地区：[1]安徽省立医院,合肥市230001

出　　处：《中国药房》1999年第5期205-206,共2页China Pharmacy

基　　金：安徽省科委"九五"科技攻关项目

摘　　要：目的：制备肠必清微丸。方法：采用正交试验设计，考察肠必清处方提取物配比微晶纤维素作赋形列比例、润湿剂乙醇浓度、粘合剂PVP浓度及快速搅拌制粒时间对微丸质量的影响。结果：优选出快速搅拌制备肠必清微丸工艺，提取物配比赋形剂比例为2：1，乙醇浓度为90％，PVP浓度为3％，搅拌时间为15min。结论：其工艺制备微丸符合设计要求，适合工业化生产。OBJECTIVE: To prepare Chang Bi Qing pellets. METHODS: By means of orthogonal design, the influence offollowing factors on quality of Chang Bi Qing pellets (CBQ) was studied: the ratio of extract of ingredients of CBQ with microcrystalline cellulose(as matrix ), the concentration of alcohol(as wetting agent ), the concentration of polyvinyl pyrrolidone(ascementing agent) and agitation time. RESULTS: The optimun preparing technology of CBQ was that the proportion of CBQextract to matrix was 2 to I and the concentration of alcohol was 90% and the concentration of PVP was 3% and the time ofagitation was 15 minutes. CONCLUSION: The adopted technology accorded with the demands of design and was suitable forindustrialization production.

关 键 词：肠必清微丸 快速搅拌 制备工艺 

分 类 号：R943[医药卫生—药剂学] R944.27[医药卫生—药学]