芪莲汤颗粒长期干预对大鼠糖尿病并发症的影响  

Effect of Long-term Treatment by Qilian-decoction Granule on Diabetic Complications in Rats

作　　者：杨李[1] 唐瑛[1] 陈芳[1] 朱以良[1] 

机构地区：[1]广州军区武汉总医院实验科,430070

出　　处：《医药导报》2011年第5期563-565,共3页Herald of Medicine

摘　　要：目的观察芪莲汤颗粒对糖尿病模型大鼠糖尿病并发症的中长期疗效。方法采用高脂饲料联合链脲佐菌素腹腔注射制备2型糖尿病大鼠模型,芪莲汤颗粒剂干预6个月。测定大鼠的认知记忆功能、肾功能、尿蛋白,统计眼部白内障发生率,病理切片观察肾脏、脑、眼底的病理改变。结果芪莲汤颗粒长期干预可以显著改善大鼠认知记忆功能和肾功能,降低尿蛋白排泄率和眼白内障发生率。结论芪莲汤颗粒剂对大鼠2型糖尿病的治疗效果较好,能够延缓糖尿病并发症的产生,减轻长期高糖高脂代谢紊乱状态对糖尿病大鼠器官实质和功能的损害。Objective To investigate the long term effect of qilian-decoction granula on diabetic complications of rats. Methods The type 2 diabetes mellitus（T2DM）model was set up on rats by i.p.injection of streptozotocin（STZ）and feeding with high calorie food.Rats were treated with qilian-decoction granula for six months.The cognition and memory capability,renal function,urine protein,incidence of cataractous were tested.Pathological changes in kidney,brain and eyeguound were observed. Results Long-term administration of qilian-decoction granula attenuated the injury on cognition and memory capability,renal function,and decreased the excretion of urine protein and cataractous incidence. Conclusion Qilian-decoction granula has a good therapeutic efficacy for T2DM,which can delay the development of diabetic complications and ameliorate the injury on organs and function of DM rats caused by long term dyslipidemia and hyperglycemia.

关 键 词：芪莲汤颗粒 糖尿病 2型 脑病 糖尿病 肾病 糖尿病 白内障 糖尿病性 

分 类 号：R286[医药卫生—中药学] R965[医药卫生—中医学]