多壁碳纳米管-酰基吡唑啉酮复合膜修饰电极测定异烟肼  

Determination of isoniazid on multi-walled carbon nanotubes-HPMαFP composite film modified glassy carbon elecrode

作　　者：宋昀[1] 李锦州[1] 刘永 

机构地区：[1]哈尔滨师范大学化学化工学院,黑龙江哈尔滨150025 [2]哈尔滨第九中学,黑龙江哈尔滨150001

出　　处：《化学研究与应用》2011年第5期578-582,共5页Chemical Research and Application

基　　金：黑龙江省自然科学基金项目(B201004)资助;哈尔滨师范大学科技发展预研基金项目(08XYG-12)资助

摘　　要：报道了一种修饰电极——多壁碳纳米管-酰基吡唑啉酮复合膜修饰玻碳电极（MWNTs/HPMαFP/GCE）,研究了异烟肼在此修饰电极上的电化学行为及反应机理。与裸GCE和MWNTs/GCE相比,异烟肼在MWNTs/HPMαFP/GCE上的氧化峰电流和检测灵敏度大大提高,表明多壁碳纳米管和酰基吡唑啉酮产生了协同增效作用。在最优化条件下,氧化峰电流与异烟肼浓度在5×10-6~8×10-4mol/L之间呈现良好的线性关系,检出限为1×10-6mol/L。该修饰电极制作简单,可用于片剂中异烟肼含量的测定。A novel modified electrode——multi-walled carbon nanotubes and acylpyrazolone composite film modified glassy carbon electrode（MWNTs/HPMαFP/GCE）for the determination of isoniazid was pxepared.Compared to the bare GCE and MWNTs/GCE,the MWNTs/HPMαFP/GCE showed an excellent electrocatalytical effect on the oxidation of isoniazid with significant increase in the peak current.The above results indicated that a synergistic effect was existed between MWNTs and HPMαFP.Under the optimum conditions,linear calibration curve was obtained within the concentration range 5×10-6 to 8×10-4 mol/L.The detection limit was 1×10-6 mol/L.This method was applied to the direct detection of isoniazid in tablet samples with satisfactory results.

关 键 词：酰基吡唑啉酮 多壁碳纳米管 异烟肼 修饰电极 

分 类 号：O657.1[理学—分析化学]