阻塞性睡眠呼吸暂停低通气综合征患者血清YKL-40变化及其临床意义  

Changes of serum levels of YKL-40 in patients with obstructive sleep apnea hypopnea syndrome and its clinical significance

作　　者：杭燕萍[1] 肖永龙[1] 张德平[1] 蔡后荣[1] 

机构地区：[1]南京大学附属鼓楼医院呼吸科,江苏南京210008

出　　处：《临床肺科杂志》2011年第6期857-859,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的观察阻塞性睡眠呼吸暂停低通气综合征(0SAHS)患者血清YKL-40水平,探讨YKL-40与0SAHS的关系。方法 38例多导睡眠图确诊的OSAHS患者,按照呼吸暂停低通气指数(AHI)分为轻度组(n=10),中度组(n=10),重度组(n=18)。另选15例年龄和体重指数(BMI)匹配的健康者作为对照组。对重度OSAHS组患者进行一夜持续气道内正压(CPAP)治疗。结果重度OSAHS组血清YKL-40水平显著高于中度组、轻度组及对照组(P<0.01),中度组高于轻度组(P<0.05)及对照组(P<0.01),轻度组与对照组间差异无统计学意义(P>0.05)。持续气道内正压(CPAP)治疗可使OSAHS患者血清YKL-40水平明显下降(P<0.01)。结论 0SAHS患者血清YKL-40水平升高,且与OSAHS严重程度有关,CPAP治疗可以降低血清YKL-40水平。Objective To investigate the serum YKL-40 levels in obstructive sleep apnea hypopnea syndrome（OSAHS） patients.Methods 38 patients with OSAHS were recruited and divided by quartiles of AHI into mild group（n=10）,moderate group（n=10） and severe group（n=18）.15 healthy volunteers with matched age and BMI were selected as control group.In addition,18 severe OSAHS patients underwent 1 day of continuous positive airway pressure（CPAP） treatment.Results Levels of YKL-40 in patients with severe OSAHS were significantly higher than that in mild to moderate OSAHS and control subjects（P〈0.01） respectively.The levels of YKL-40 in patients with moderate OSAHS were higher than that in mild OSAHS and control subjects respectively（P〈0.05 and P〈0.01）,whereas the difference between mild OSAHS and control subjects had no statistical significance（P〉0.05）.After 1 day of CPAP treatment,serum YKL-40 levels were strikingly declined（P〈0.01）.Conclusion The results of this study indicate that severity of OSAHS independently associates with serum levels of YKL-40,CPAP treatment could effectively decrease YKL-40 levels in patients with OSAHS.

关 键 词：阻塞性睡眠呼吸暂停低通气综合症 YKL-40 持续气道内正压通气 

分 类 号：R766[医药卫生—耳鼻咽喉科]