Hck基因多态性与慢性阻塞性肺疾病的相关性研究  

A correlational study between Hck gene polymorphism and COPD susceptibility

作　　者：刘蔺[1,2] 陈磊[2] 王开绿[1] 黄玲[1] 黄娜[2] 王晓珍[2] 杨小东[2] 

机构地区：[1]绵阳市第三人民医院呼吸内科,四川绵阳621000 [2]四川大学华西医院呼吸内科,四川成都610041

出　　处：《临床肺科杂志》2011年第6期866-867,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨造血细胞激酶(Hck)基因多态性与慢性阻塞性肺疾病(COPD)易感性的相互关系。方法 PCR法分析120例汉族COPD患者(COPD组)和100例汉族正常人(对照组)Hck 8,656-insertion(I)/deletion(D)的基因多态性。结果 COPD组与对照组均存在Hck 8,656-I/D基因多态性,两组间的基因型频率分布为8,656-I/D(38.3%,34%),8,656-I/I(1.7%,5%),8,656-D/D(60%,61%);等位基因频率分布为8,656-D(79.2%,78%),8,656-I(20.8%,22%),各组间差异均无统计学意义(P>0.05)。结论我国汉族人群中存在Hck 8,656-I/D基因多态性,但这种基因多态性可能不是我国汉族COPD的遗传易感因素。Objective To investigate the relationship between hematopoietic cell kinase（Hck） gene polymorphism and chronic obstructive pulmonary disease（COPD） susceptibility.Methods PCR assay was used to analyze the Hck 8,656-insertion（I）/deletion（D）gene polymorphism between 120 COPD cases and 100 healthy controls from a Chinese Han population.Results The Hck 8,656-I/D gene polymorphism was found in both COPD and control groups,with the distribution of genotype frequency 8,656-I/D（38.3%,34%）,8,656-I/I（1.7%,5%）,8,656-D/D（60%,61%）,and allele frequency 8,656-D（79.2%,78%）,8,656-I（20.8%,22%） in COPD and control groups respectively.However,no significant difference was revealed among different groups（P〉0.05）.Conclusion There is no association of the Hck 8,656-I/D gene polymorphism with COPD susceptibility in a Chinese Han population.

关 键 词：基因多态性 造血细胞激酶 慢性阻塞性肺疾病 

分 类 号：R563.9[医药卫生—呼吸系统]