注射用甲磺酸帕珠沙星、盐酸加替沙星注射液在5%转化糖注射液中的配伍稳定性考察  

Stability of pazufloxacin mesilate for injection,gatifloxacin hydrochloride injection in 5% invert sugar injection

作　　者：田俊红[1] 郑芳[2] 朱雪松[2] 

机构地区：[1]湖北省十堰市东风公司茅箭医院药剂科 [2]湖北医药学院附属东风医院药剂部,湖北十堰442008

出　　处：《安徽医药》2011年第5期557-559,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的考察注射用甲磺酸帕珠沙星、盐酸加替沙星注射液分别与5%转化糖注射液配伍的稳定性,为临床合理用药提供依据。方法在室温(20±1)℃下,将两种注射用抗生素分别与5%转化糖注射液配伍,在8 h内,观察各配伍溶液的pH和外观变化,并采用HPLC法测定各配伍溶液中主药成分的相对含量。结果 8 h内,甲磺酸帕珠沙星、盐酸加替沙星与5%转化糖注射液配伍后,pH、外观和相对含量均无明显变化。结论在室温(20±1)℃条件下、8 h内,注射用甲磺酸帕珠沙星和盐酸加替沙星注射液分别与5%转化糖注射液的配伍液稳定。Aim To study the stability of pazufloxacin mesilate for injection and gatifloxacin hydrochloride for injection respectively in 5% invert sugar injection in order to supply evidence of clinical rational administration.Methods The changes of pH values and external appearances of the two antibiotics were observed after mixed with 5% invert sugar injection respectively and their relative contents were determined by HPLC within 8h after mixing at ambient temperature（20±1）℃.Results No significant changes were noted in the relative contents,appearance and pH values of pazufloxacin mesilate and gatifloxacin hydrochloride with 5% invert sugar injection within 8 h.Conclusion The two kinds of mixed solution were stable at ambient temperature（20±1）℃within 8 h.

关 键 词：甲磺酸帕珠沙星 盐酸加替沙星 5%转化糖注射液 配伍稳定性 

分 类 号：R944[医药卫生—药剂学]