呼吸道药物递送—雾化吸入剂的研究进展  

Pulmonary delivery drugs:developments in nebulizers

作　　者：王兆东[1,2] 邓家华[2] 周建平[1] 金方[2] 

机构地区：[1]中国药科大学药剂学教研室,南京210009 [2]上海医药工业研究院上海市呼吸系统药物工程技术研究中心,上海200437

出　　处：《世界临床药物》2011年第5期316-320,I0001,I0002,共7页World Clinical Drug

基　　金：上海市重点科技攻关专项资助(项目编号10dz2251400)

摘　　要：吸入给药是防治哮喘、慢性阻塞性肺疾病(COPD)等呼吸道疾病的首选给药方式。常见的吸入给药制剂包括压力定量吸入剂、干粉吸入剂和雾化吸入剂。与前两者相比,雾化吸入剂具有处方简单、剂量灵活性好、吸入效果受吸气模式影响较小等特点。并在最近十几年里取得了快速发展,由过去仅在医院使用逐渐向便携化、智能化发展。本文就目前几种主要雾化器的工作原理、研究现状及其临床应用进行综述。Inhalation therapy is the first choice for the treatment of respiratory diseases,such as asthma and chronic obstructive pulmonary diseases（COPD）.In clinic,the most common used dosage forms for inhaled drug administration are pressurized metered-dose inhalers（pMDI）,dry powder inhalers（DPI） and nebulizers.Among them the nebulizers possess the advantages including simplified formulation,dosage adjustment and less impact by inhalation profiles.In recent decade,a significant progress of nebulizers has been made.It offers tremendous possibilities for the development of portable and smart nebulizers in future.This review discusses the operational principle,research status and clinical use of several major nebulizers.

关 键 词：雾化吸入剂 喷射雾化器 超声雾化器 振动筛雾化器 

分 类 号：R974[医药卫生—药品] R944[医药卫生—药学]