大黄治疗糖尿病肾病的研究概况  

Rhubarb treatment of diabetic nephropathy research situation

作　　者：许成群 徐明松[1] 王元[1] 

机构地区：[1]淮北市中医院,安徽淮北235000

出　　处：《中医药导报》2011年第4期123-125,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：安徽省卫生厅科研计划项目(2009ZY49)

摘　　要：通过临床文献的搜集、整理和归纳等方法从病因病机(肾络瘀阻、浊毒内停、微型癥瘕)、临床治疗(复方治疗、中成药、单味药、中西医结合)、机理研究(对细胞因子的调节作用、对糖、脂代谢的影响、对血管活性因子的影响)等3个方面对近6年来大黄治疗糖尿病肾病(DN)的研究进展进行了分析和研究。结果表明大黄能抑制系膜细胞及肾小管上皮细胞增生,减轻代偿性肥大,延缓肾小球硬化,改善肾衰患者的高凝、高黏状态,改善肾血流量,保护残余肾功能,减少蛋白尿,延缓DN的发展。糖尿病肾病运用大黄辨证治疗,能提高临床疗效。Through the clinical literature collecting,sorting and concludes from etiology（methods of renal winding stasis resistance,turbidity poison inside remove lump）,stop,miniature clinical therapy（compound treatment,proprietary Chinese medicine,single herb,combined chinese and western medicine）,mechanism research（the regulation effects of cytokines,sugar,fat metabolism,influence of the influence of vascular active factor） from three aspects of nearly six years the rhubarb treatment of diabetic nephropathy（DN） the research progress on analysis and research.Results show that chinese rhubarb can inhibit mesangium cells and renal tubular epithelial hyperplasia,compensatory sex hypertrophy,reduce the delay,improve glomerular sclerosis patients with kidney failure high pour-point,high adhesion state,improve blood flow to kidneys residual renal function,reduce albuminuria protect delay the development of a DN.diabetic nephropathy dialectical therapy using rhubarb,can improve the clinical effect.

关 键 词：糖尿病肾病 大黄 中医药疗法 综述 

分 类 号：R255.4[医药卫生—中医内科学]